9 Papers
28 Citations
Mainul Hoque is an academic researcher from University of Medicine and Dentistry of New Jersey. The author has contributed to research in topics: Polyadenylation & Gene. The author has an hindex of 7, co-authored 9 publications. Previous affiliations of Mainul Hoque include University of Oxford.
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Papers
Analysis of alternative cleavage and polyadenylation by 3′ region extraction and deep sequencing
Mainul Hoque,Zhe Ji,Dinghai Zheng,Wenting Luo,Wencheng Li,Bei You,Ji Yeon Park,Ghassan Yehia,Bin Tian +8 more
TL;DR: Quantitative analysis of APA isoforms indicated that promoter-distal pAs, regardless of intron or exon locations, become more abundant during embryonic development and cell differentiation and that upregulated isoforms have stronger pA, suggesting global modulation of the 3′ end–processing activity in development and differentiation.
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Analysis of C. elegans intestinal gene expression and polyadenylation by fluorescence-activated nuclei sorting and 3′-end-seq
Simon Haenni,Zhe Ji,Mainul Hoque,Nigel Rust,Helen E. Sharpe,Ralf Eberhard,Cathy Browne,Michael O. Hengartner,Jane Mellor,Bin Tian,Andre Furger +10 more
TL;DR: A novel experimental approach for efficient determination of tissue-specific transcriptomes involving the rapid release and purification of nuclei from major tissues of post-embryonic animals by fluorescence-activated nuclei sorting (FANS), followed by deep sequencing of linearly amplified 3′-end regions of transcripts (3′- end-seq).
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The conserved intronic cleavage and polyadenylation site of CstF-77 gene imparts control of 3' end processing activity through feedback autoregulation and by U1 snRNP
Wenting Luo,Zhe Ji,Zhenhua Pan,Bei You,Mainul Hoque,Wencheng Li,Samuel I. Gunderson,Bin Tian +7 more
TL;DR: P perturbation of CstF-77 expression leads to widespread alternative cleavage and polyadenylation (APA) and disturbance of cell proliferation and differentiation, suggesting that the C/P activity in the cell can be cross-regulated by splicing, leading to coordination between these two processes.
Accurate mapping of cleavage and polyadenylation sites by 3' region extraction and deep sequencing.
TL;DR: A method named 3' region extraction and deep sequencing (3'READS) is developed, which completely addresses mispriming issues and allows quantitative analysis of alternative cleavage and polyadenylation (APA) isoforms and gene expression.
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Patent
Method of preventing survival of retrovirally cells and of inhibiting formation of infectious retroviruses
H. M. Hanauske-Abel,Paul Palumbo,B. M. Cracchiolo,Myung Hee Park,Edith C. Wolff,Axel-Rainer Hanauske,Michael B. Mathews,Deepti Saxena,Mainul Hoque +8 more
- 01 Dec 2004
TL;DR: In this article, compounds and pharmaceutical compositions which are highly effective at inhibiting the accumulation of spliced and unspliced viral transcripts and their utilization for viral protein synthesis at cellular ribosomes, and the formation of the hypusine residue in cellular eIF-5A precursor proteins, are revealed.
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