Maining Li
Nanjing Medical University
5 Papers
Maining Li is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: T cell & Inflammation. The author has an hindex of 2, co-authored 4 publications.
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Papers
Indolepropionic acid reduces obesity‐induced metabolic dysfunction through colonic barrier restoration mediated via tuft cell‐derived IL‐25
Lu Chen,Yuxuan Yang,Siyu Sun,Yuan Xie,Cailong Pan,Maining Li,Chen Li,Yu Liu,Zhipeng Xu,Wentao Liu,Minjun Ji +10 more
TL;DR: It is demonstrated that IPA supplementation prevents the development of high‐fat diet‐induced obesity and metabolic disorders by restoring tuft cell‐interleukin‐25‐mediated colonic barrier integrity; hence, IPA could be a potential agent for treatment of obesity.
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Therapeutic potential of fucoidan in the reduction of hepatic pathology in murine schistosomiasis japonica
Xueqi Bai,Maining Li,Xinyue Wang,Hao Chang,Yangyue Ni,Chen Li,Kai-Yue He,Huiquan Wang,Yuxuan Yang,Tian Tian,Min Hou,Minjun Ji,Zhipeng Xu +12 more
TL;DR: An important role of natural fucoidan is suggested in reducing hepatic pathology in the progress of S. japonicum infection with a stronger Treg response, which may reveal a new potential therapeutic strategy for hepatic disease caused by parasitic chronic infection.
Therapeutic inhibition of miR-802 protects against obesity through AMPK-mediated regulation of hepatic lipid metabolism.
Yangyue Ni,Zhipeng Xu,Chen Li,Yuxiao Zhu,Ran Liu,Fan Zhang,Hao Chang,Maining Li,Liang Sheng,Li Zhong,Min Hou,Lin Chen,Hong You,Donald P. McManus,Wei Hu,Yinong Duan,Yu Liu,Minjun Ji +17 more
TL;DR: A link between decreased miR-802 and impaired lipid metabolism in Schistosoma japonicum infected mice is shown and the therapeutic potential of Sjp40 is identified in treating obesity-related fatty liver.
P21 activated kinase‐1 (PAK1) in macrophages is required for promotion of Th17 cell response during helminth infection
Hao Chang,Kai-Yue He,Chen Li,Yangyue Ni,Maining Li,Lin Chen,Min Hou,Zikai Zhou,Zhipeng Xu,Min-Jun Ji,Min-Jun Ji +10 more
TL;DR: PAK1 enhances macrophage activation through promoting IRF1 nuclear translocation in an NF‐κB‐dependent pathway, resulting in promoting Th17 cell differentiation through inducing IL‐6 production and it is suggested that PAK1/IRF1 axis‐dependent immunomodulation can ameliorate certain T cell–based immune pathologies.