Maike Werner
Eindhoven University of Technology
11 Papers
1 Citations
Maike Werner is an academic researcher from Eindhoven University of Technology. The author has contributed to research in topics: Chemistry & Curvature. The author has an hindex of 5, co-authored 8 publications. Previous affiliations of Maike Werner include Charité & University of Twente.
Chat about Author
Papers
Surface curvature differentially regulates stem cell migration and differentiation via altered attachment morphology and nuclear deformation
Maike Werner,Sébastien Blanquer,Suvi Haimi,Gabriela Korus,John W. C. Dunlop,Georg N. Duda,Dirk W. Grijpma,Ansgar Petersen +7 more
TL;DR: The findings of this study demonstrate a so far missing link between 3D surface curvature and hMSC behavior and will help to better understand the role of extracellular matrix architecture in health and disease and give new insights in how 3D geometries can be used as a cell‐instructive material parameter in the field of biomaterial‐guided tissue regeneration.
Surface curvature in triply-periodic minimal surface architectures as a distinct design parameter in preparing advanced tissue engineering scaffolds
Sébastien Blanquer,Maike Werner,Markus Hannula,Shahriar Sharifi,Guillaume Lajoinie,David Eglin,Jari Hyttinen,André A. Poot,Dirk W. Grijpma +8 more
TL;DR: This study designs eight triply-periodic minimal surface (TPMS)-based scaffolds, providing the same porosity and the same number of unit cells, while presenting different surface curvatures, to decipher the biofunctional role of the surface curvature of scaffolds intended for tissue engineering applications.
159
Cell-Perceived Substrate Curvature Dynamically Coordinates the Direction, Speed, and Persistence of Stromal Cell Migration.
Maike Werner,Ansgar Petersen,Nicholas A. Kurniawan,Carlijn V. C. Bouten +3 more
- 01 Oct 2019
TL;DR: It is demonstrated that cell migration is dynamically guided by the perceived curvature of the underlying substrate, providing an important biomaterial design parameter for instructing cell migration in tissue engineering and regenerative medicine.
84
Mesoscale substrate curvature overrules nanoscale contact guidance to direct bone marrow stromal cell migration.
TL;DR: This work demonstrates that geometrical cues of up to 10× cell size can play a dominant role in directing hBMSC alignment and migration and that the effect of nanoscale contact guidance can even be overruled by mesoscale curvature guidance.
75
Cell Migration: Surface Curvature Differentially Regulates Stem Cell Migration and Differentiation via Altered Attachment Morphology and Nuclear Deformation (Adv. Sci. 2/2017)
Maike Werner,Maike Werner,Sébastien Blanquer,Suvi Haimi,Gabriela Korus,John W. C. Dunlop,Georg N. Duda,Dirk W. Grijpma,Ansgar Petersen +8 more
TL;DR: While concave surfaces promote stem cell migration, convex surfaces enhance cell specification into bone cells, a process driven by curvature‐dependent forces on the cell's nucleus.
7