Mahtab Sharifi
University College London
8 Papers
32 Citations
Mahtab Sharifi is an academic researcher from University College London. The author has contributed to research in topics: Familial hypercholesterolemia & Gene. The author has an hindex of 6, co-authored 8 publications. Previous affiliations of Mahtab Sharifi include Royal Free London NHS Foundation Trust & British Heart Foundation.
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Papers
Refinement of Variant Selection for the LDL Cholesterol Genetic Risk Score in the Diagnosis of the Polygenic Form of Clinical Familial Hypercholesterolemia and Replication in Samples from 6 Countries
Marta Futema,Sonia Shah,Sonia Shah,Jackie A. Cooper,KaWah Li,Ros Whittall,Mahtab Sharifi,Olivia Goldberg,Euridiki Drogari,Vasiliki Mollaki,Albert Wiegman,Joep C. Defesche,Maria Nicoletta D'Agostino,Antonietta D'Angelo,Paolo Rubba,Giuliana Fortunato,Małgorzata Waluś-Miarka,Robert A. Hegele,Mary Aderayo Bamimore,Ronen Durst,Eran Leitersdorf,Monique T. Mulder,Jeanine E. Roeters van Lennep,Eric J.G. Sijbrands,John C. Whittaker,John C. Whittaker,Philippa J. Talmud,Steve E. Humphries +27 more
TL;DR: A 6-SNP LDL-C score consistently distinguishes FH/M- patients from healthy individuals and indicates a >95% likelihood of a polygenic explanation of their increased cholesterol-raising alleles.
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Genetic Architecture of Familial Hypercholesterolaemia.
TL;DR: New genotyping methods such as next-generation sequencing will provide a better understanding of the genetic architecture of FH and its impact on the clinical presentation, as well as the management of patients based on their underlying genetic factors.
Cardiovascular risk stratification in familial hypercholesterolaemia
TL;DR: It is essential to have a better screening programme to prioritise the candidates for treatment with the most severe form of FH and at higher risk of coronary events and the utility of new imaging techniques and new cardiovascular biomarkers remains to be determined in prospective trials.
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The genetic spectrum of familial hypercholesterolemia in south-eastern Poland
Mahtab Sharifi,Małgorzata Walus-Miarka,Barbara Idzior-Waluś,Maciej T. Malecki,Marek Sanak,Ros Whittall,Ka Wah Li,Marta Futema,Steve E. Humphries +8 more
TL;DR: These results confirm the genetic heterogeneity of FH in Poland, which should be considered when designing a diagnostic strategy in the country, and suggest that in the majority of patients where no mutation can be found, there is likely to be a polygenic cause of their high cholesterol level.
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