Magdi H. Yacoub
National Institutes of Health
1283 Papers
16.5K Citations
Magdi H. Yacoub is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Transplantation & Medicine. The author has an hindex of 109, co-authored 1267 publications. Previous affiliations of Magdi H. Yacoub include Royal Free Hospital & Hammersmith Hospital.
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Papers
Modulation of acetylcholine release from parasympathetic nerves innervating guinea-pig and human trachea by endomorphin-1 and -2.
Hema J Patel,Priya Venkatesan,James Halfpenny,Magdi H. Yacoub,Alyson Fox,Peter J. Barnes,Maria G. Belvisi +6 more
TL;DR: Naloxone prevented the inhibition by endomorphin-1 and -2 in both guinea-pig and human trachea, suggesting that these peptides can inhibit cholinergic, parasympathetic neurotransmission to the airways via the activation of classical opioid receptors.
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The role of the cardiac Na+/Ca2+ exchanger in reverse remodeling: relevance for LVAD-recovery.
Cesare M. Terracciano,Maren U Koban,Gopal K. Soppa,Urszula Siedlecka,Joon Ha Lee,Mark A. Stagg,Magdi H. Yacoub +6 more
TL;DR: It is proposed that increased NCX function may be associated with reverse remodeling in patients and that factors that regulateNCX function (i.e., phosphorylation or intracellular [Na+]) other than NCX expression levels alone, may have detrimental consequences on cardiac function.
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Identification of antigen presenting cells in normal and transplanted human heart: importance of endothelial cells.
TL;DR: In normal heart presentation of allogeneic class II is by the intercellular adhesion molecule-1-positive endothelial cells, and after transplantation, there is an influx of recipient cells of the macrophage/dendritic series which are probably able to process allogeneIC class II.
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Pharmacological Assessment of the Nitric-Oxide Synthase Isoform Involved in Eosinophilic Inflammation in a Rat Model of Sephadex-Induced Airway Inflammation
Mark A. Birrell,Kerryn McCluskie,El-Bdaoui Haddad,Cliff H. Battram,Stephen E Webber,Martyn Foster,Magdi H. Yacoub,Maria G. Belvisi +7 more
TL;DR: It appears that constitutive, not inducible, NOS isoforms are important in NO production in models of allergic inflammation, which questions whether there is a role for iNOS inhibitors as therapy for the treatment of asthma.
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Clenbuterol Induces Cardiac Myocyte Hypertrophy via Paracrine Signalling and Fibroblast-derived IGF-1
Pankaj K. Bhavsar,Nigel J. Brand,Leanne E. Felkin,Pradeep K. Luther,Martin E. Cullen,Magdi H. Yacoub,Paul J.R. Barton +6 more
TL;DR: Data show that clenbuterol acts to induce mild cardiac hypertrophy in cardiac myocytes via paracrine signalling involving fibroblast-derived IGF-1.
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