Magdi H. Yacoub
National Institutes of Health
1283 Papers
16.5K Citations
Magdi H. Yacoub is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Transplantation & Medicine. The author has an hindex of 109, co-authored 1267 publications. Previous affiliations of Magdi H. Yacoub include Royal Free Hospital & Hammersmith Hospital.
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Papers
Cardiac and peripheral vascular responses to adrenoceptor stimulation and blockade after cardiac transplantation.
TL;DR: Transplant patients who were previously in severe heart failure have normal left ventricular inotropic response to beta 1 activation and blockade, exaggerated chronotropicresponse to dobutamine and reduced sensitivity to stimulation with alpha 1-adrenoceptor agonists, consistent with a differential response of adrenoceptors to long-term stimulation after cardiac transplantation.
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Identification of the protein kinase C isoenzymes in human lung and airways smooth muscle at the protein and mRNA level
Benjamin L. J. Webb,Mark A. Lindsay,Joachim Seybold,Nigel J. Brand,Magdi H. Yacoub,El Bdaoui Haddad,Peter J. Barnes,Ian M. Adcock,Mark A. Giembycz +8 more
TL;DR: RT-PCR analyses confirmed the expression of the PKC isoforms detected at the protein level and, in addition, identified mRNA for PKC delta, suggesting that they subserve diverse multifunctional roles in these tissues.
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Functional and autoradiographic evidence for endothelin 1 receptors on human and rat cardiac myocytes. Comparison with single smooth muscle cells.
TL;DR: Endothelin 1 had a pronounced effect on shortening in both rat and human myocytes, and the magnitude of the effect was comparable to that of the alpha-adrenoceptor agonist phenylephrine.
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Hemodynamics and left ventricular mass regression following implantation of the Toronto SPV stentless porcine valve
David S. Bach,Tirone E. David,Magdi H. Yacoub,John Pepper,Bernard S. Goldman,Jeremy R Wood,Edward D. Verrier,Michael R Petracek,Victor Aldrete,Michael Rosenbloom,Hormoz Azar,Harry Rakowski +11 more
TL;DR: The Toronto SPV valve has an excellent hemodynamic profile supported by significant regression of LV hypertrophy in the year after implantation and data through 3 years demonstrates maintenance of low gradients and freedom from significant aortic regurgitation.
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Irreversible morphological changes contributing to depressed cardiac function after surgery for chronic aortic regurgitation.
R. M. Donaldson,Florio R,A. F. Rickards,J. G. Bennett,Magdi H. Yacoub,Donald N. Ross,E.G.J. Olsen +6 more
TL;DR: Changes in left ventricular mass, volume, morphology, and histochemistry were analysed in 67 patients undergoing surgery for chronic aortic regurgitation to identify variables predictive of postoperative haemodynamic improvement.
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