Maen Zeino
University of Mainz
23 Papers
159 Citations
Maen Zeino is an academic researcher from University of Mainz. The author has contributed to research in topics: Cancer cell & Cytotoxicity. The author has an hindex of 15, co-authored 23 publications.
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Papers
New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids
Christoph Reiter,Tony Fröhlich,Maen Zeino,Manfred Marschall,Hanife Bahsi,Maria Leidenberger,Oliver Friedrich,Barbara Kappes,Frank Hampel,Thomas Efferth,Svetlana B. Tsogoeva +10 more
TL;DR: The application of 1,2,4-trioxane-ferrocene hybrids against HCMV is unprecedented and demonstrated here for the first time.
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Synthesis and study of cytotoxic activity of 1,2,4-trioxane- and egonol-derived hybrid molecules against Plasmodium falciparum and multidrug-resistant human leukemia cells.
Christoph Reiter,Aysun Çapcı Karagöz,Tony Fröhlich,Volker Klein,Maen Zeino,Katrin Viertel,Jana Held,Benjamin Mordmüller,Safiye Emirdağ Öztürk,Hüseyin Anil,Thomas Efferth,Svetlana B. Tsogoeva +11 more
TL;DR: Interestingly, hybrid 9 containing a 1,2,4-trioxane and a ferrocene fragment has shown to be the most effective among the studied hybrids against the tested multidrug-resistant leukemia CEM/ADR5000 cells and possesses a degree of cross-resistance of 2.34.
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Cytotoxicity of three naturally occurring flavonoid derived compounds (artocarpesin, cycloartocarpesin and isobavachalcone) towards multi-factorial drug-resistant cancer cells
Victor Kuete,Armelle T. Mbaveng,Maen Zeino,Christian D. Fozing,Bathelemy Ngameni,Gilbert D W F Kapche,Bonaventure T. Ngadjui,Thomas Efferth +7 more
TL;DR: The three tested flavonoids and mostly chalcone 3 are potential cytotoxic natural products that deserve more investigations to develop novel antineoplastic drugs against multifactorial drug-resistant cancers.
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Biopiracy of natural products and good bioprospecting practice
Thomas Efferth,Mita Banerjee,Norbert W. Paul,Sara Abdelfatah,Joachim Arend,Gihan Elhassan,Sami Hamdoun,Rebecca Hamm,Chunlan Hong,Onat Kadioglu,Janine Naß,Dominic Ochwangi,Edna Ooko,Nadire Özenver,Mohamed E.M. Saeed,Mathias Schneider,Ean-Jeong Seo,Ching Fen Wu,Ge Yan,Maen Zeino,Qiaoli Zhao,M. S. Abu-Darwish,Kai Andersch,Gladys Alexie,Dawn Bessarab,Dipita Bhakta-Guha,Vanderlan da Silva Bolzani,Else Dapat,F. V. Donenko,Monika Efferth,Henry Johannes Greten,Leslie Gunatilaka,Ahmed Hussein,Asuman Karadeniz,Hassan E. Khalid,Victor Kuete,Ik-Soo Lee,Liang Liu,Jacob O. Midiwo,Rodrigo Mora,Hiroshi Nakagawa,Olipa D Ngassapa,C. Noysang,Leonida K. Omosa,Fred Hwiemtun Roland,Abdelaaty A. Shahat,Antoine M. Saab,Elfatih M. Saeed,Letian Shan,Salam J.J. Titinchi +49 more
TL;DR: An overview of the legal frameworks, some exemplary cases of biopiracy and bioprospecting as excellent forms of utilization of natural resources are discussed, and ways, in which the interests of indigenous people especially from developing countries can be secured are discussed.
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The ability of molecular docking to unravel the controversy and challenges related to P-glycoprotein--a well-known, yet poorly understood drug transporter.
TL;DR: Despite the various challenges, molecular docking should not be underestimated as differences between the distinct groups were significant and when it comes to defining the binding site, care must be taken, since consensus throughout literature could not be reached.
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