Madeleine E. Cunningham
University of Glasgow
14 Papers
22 Citations
Madeleine E. Cunningham is an academic researcher from University of Glasgow. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 6, co-authored 8 publications.
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Papers
C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy
Rhona McGonigal,Madeleine E. Cunningham,Denggao Yao,Jennifer A. Barrie,Sethu Sankaranarayanan,Simon N. Fewou,Koichi Furukawa,Ted A. Yednock,Hugh J. Willison +8 more
TL;DR: It is demonstrated that neutralising C1q function attenuates injury with a consequent neuroprotective effect in acute GBS models and promises to be a useful new target for human therapy.
Neuronal Expression of GalNAc Transferase Is Sufficient to Prevent the Age-Related Neurodegenerative Phenotype of Complex Ganglioside-Deficient Mice
Denggao Yao,Rhona McGonigal,Jennifer A. Barrie,Joanna Cappell,Madeleine E. Cunningham,Gavin R. Meehan,Simon N. Fewou,Julia M. Edgar,Edward G. Rowan,Yuhsuke Ohmi,Keiko Furukawa,Koichi Furukawa,Peter J. Brophy,Hugh J. Willison +13 more
TL;DR: Results indicate that neuronal rather than glial gangliosides are critical to the age-related maintenance of nervous system integrity.
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Anti-ganglioside antibodies are removed from circulation in mice by neuronal endocytosis
Madeleine E. Cunningham,Rhona McGonigal,Gavin R. Meehan,Jennifer A. Barrie,Denggao Yao,Susan K. Halstead,Hugh J. Willison +6 more
TL;DR: This highlights the limitations of serum antibody measurements and suggests a possible entry mechanism for their central effects, and describes an uptake pathway for these autoantibodies at motor nerve terminals and their delivery into the brain parenchyma.
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Perisynaptic Schwann cells phagocytose nerve terminal debris in a mouse model of Guillain-Barré syndrome
Madeleine E. Cunningham,Gavin R. Meehan,Sophie Robinson,Denggao Yao,Rhona McGonigal,Hugh J. Willison +5 more
TL;DR: Data suggest that pSCs, rather than inflammatory cells, are the major cellular vehicle for axonal debris clearance following distal nerve injury, in contrast to larger nerve bundles where macrophage‐mediated clearance predominates.
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Schwann cell nodal membrane disruption triggers bystander axonal degeneration in a Guillain-Barré syndrome mouse model
Rhona McGonigal,Clare Campbell,Jennifer A. Barrie,Denggao Yao,Madeleine E. Cunningham,Colin Crawford,Simon Rinaldi,Edward G. Rowan,Hugh J. Willison +8 more
TL;DR: These models differentiate the distinctly different axonopathic pathways under axonal and glial membrane targeting conditions, and provide insights into primary and secondary axonal injury, currently a major unsolved area in GBS research.
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