Mackenzie McGee
St. Jude Children's Research Hospital
7 Papers
14 Citations
Mackenzie McGee is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 6, co-authored 6 publications. Previous affiliations of Mackenzie McGee include University of Tennessee Health Science Center.
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Papers
Improved Intratumoral Oxygenation Through Vascular Normalization Increases Glioma Sensitivity to Ionizing Radiation
Mackenzie McGee,J. Blair Hamner,J. Blair Hamner,Regan F. Williams,Regan F. Williams,Shannon F. Rosati,Thomas L. Sims,Thomas L. Sims,Catherine Y.C. Ng,M. Waleed Gaber,Christopher Calabrese,Jianrong Wu,Amit C. Nathwani,Christopher Duntsch,Thomas E. Merchant,Andrew M. Davidoff,Andrew M. Davidoff +16 more
TL;DR: Bvacizumab and continuous delivery of IFN-beta each induced significant changes in glioma vascular physiology, improving intratumoral oxygenation and enhancing the antitumor activity of ionizing radiation.
Organ-specific models of Streptococcus pneumoniae disease
Carlos J. Orihuela,Geli Gao,Mackenzie McGee,Jun Yu,Kevin P. Francis,Elaine Tuomanen +5 more
- 01 Jan 2003
TL;DR: These studies unambiguously characterize 3 distinct models of the natural course of pneumococcal infection, which provides a framework for detailed molecular modeling ofneumococcal virulence determinants at specific stages of disease.
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The efficacy of combination therapy using adeno-associated virus—interferon β and trichostatin A in vitro and in a murine model of neuroblastoma
John B. Hamner,Thomas L. Sims,Thomas L. Sims,Aaron Cutshaw,Paxton V. Dickson,Paxton V. Dickson,Shannon F. Rosati,Mackenzie McGee,Catherine Y.C. Ng,Andrew M. Davidoff,Andrew M. Davidoff +10 more
TL;DR: Data show that both TSA and IFN-beta inhibit neuroblastoma growth and that the combination may potentially provide a unique way to treat this difficult disease.
17
IFN-β Restricts Tumor Growth and Sensitizes Alveolar Rhabdomyosarcoma to Ionizing Radiation
Thomas L. Sims,Mackenzie McGee,Regan F. Williams,Adrianne L. Myers,Lorraine Tracey,J. Blair Hamner,Catherine Y.C. Ng,Jianrong Wu,M. Waleed Gaber,Beth McCarville,Amit C. Nathwani,Andrew M. Davidoff +11 more
TL;DR: The combination of IFN-β and ionizing radiation showed synergy against ARMS by sensitizing tumor cells to the cytotoxic effects of ionizing Radiation and by altering tumor vasculature, thereby improving oxygenation, may be an effective combination for treatment of ARMS.
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Ncog-03. impact of the rate of radiographic response (rr) of brain metastases (bm) to whole brain radiation therapy (wbrt) on neurocognitive function (ncf) on nrg-cc001
Kiran Devisetty,Stephanie L. Pugh,Paul Brown,Vinai Gondi,Jeffrey S. Wefel,Abhishek A. Solanki,Tomy P. Kalapparambath,Grant Harmon,Anjali L. Saripalli,Brian Chou,Bhanu Prasad Venkatesulu,T. Boike,Vijayananda Kundapur,David Roberge,Joseph Bovi,Mackenzie McGee,Tim J. Kruser,Andrew M. Baschnagel,Kenneth Y. Usuki,Minesh P. Mehta,Lisa A. Kachnic +20 more
TL;DR: The NRG-CC001 randomized clinical trial required pre-specified MRI protocols at baseline and 6-months, providing a uniform dataset to investigate if RR correlates with NCF changes as discussed by the authors .