Maciej Sobczyński
University of Wrocław
37 Papers
103 Citations
Maciej Sobczyński is an academic researcher from University of Wrocław. The author has contributed to research in topics: Biology & Innate immune system. The author has an hindex of 10, co-authored 31 publications.
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Papers
Significant decline in pneumonia admission rate after the introduction of routine 2+1 dose schedule heptavalent pneumococcal conjugate vaccine (PCV7) in children under 5 years of age in Kielce, Poland.
TL;DR: PCV7 may play an important role in reducing the burden of pneumonia in Poland, and in children younger than 2 years of age, the age group targeted for vaccination, pneumonia-related healthcare utilization declined substantially following PCV7 introduction.
ALCAM and CD6 — multiple sclerosis risk factors
Marta Wagner,Małgorzata Bilińska,Anna Pokryszko-Dragan,Maciej Sobczyński,Małgorzata Cyrul,P. Kusnierczyk,Monika Jasek +6 more
TL;DR: The analysis revealed that the risk of the disease for AA individuals in rs12360861 was almost 3.0-fold lower in comparison to GG individuals, and in the case of the CD6 gene, not only polymorphisms but also mRNA expression level are associated with MS.
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Polymorphisms in CD28, CTLA-4, CD80 and CD86 genes may influence the risk of multiple sclerosis and its age of onset.
Marta Wagner,Maciej Sobczyński,Lidia Karabon,Małgorzata Bilińska,Anna Pokryszko-Dragan,Edyta Pawlak-Adamska,Małgorzata Cyrul,Piotr Kuśnierczyk,Monika Jasek +8 more
TL;DR: The investigation revealed that in HLA-DRB1*15:01 negative individuals, G allele in rs231775A NG of CTLA-4 gene was associated with higher risk of multiple sclerosis, and an interaction between three polymorphisms, associated with the age of MS onset.
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MS risk allele rs1883832T is associated with decreased mRNA expression of CD40.
Marta Wagner,Maciej Sobczyński,Małgorzata Bilińska,Anna Pokryszko-Dragan,Małgorzata Cyrul,Piotr Kuśnierczyk,Monika Jasek +6 more
TL;DR: The potential role of impaired CD40-CD40L interaction in developing of multiple sclerosis was demonstrated and individuals possessing CT and TT genotypes (predisposing to MS) had decreased level of CD40 mRNA in comparison to those with CC.
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Hampering Herpesviruses HHV-1 and HHV-2 Infection by Extract of Ginkgo biloba (EGb) and Its Phytochemical Constituents.
TL;DR: It was revealed that flavonoids, especially isorhamnetin, are responsible for the antiviral activity of EGb, which showed the most potent antiviral potency compared to isorHAMnetin.