Maaike Hum
Queen's University
7 Papers
83 Citations
Maaike Hum is an academic researcher from Queen's University. The author has contributed to research in topics: Heme oxygenase & Heme. The author has an hindex of 4, co-authored 7 publications.
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Papers
A novel role for ezrin in breast cancer angio/lymphangiogenesis
Abdi Ghaffari,Victoria Hoskin,Alvin Szeto,Maaike Hum,Navid Liaghati,Kanji Nakatsu,Yolanda Madarnas,Sandip SenGupta,Bruce E. Elliott +8 more
TL;DR: A novel function for ezrin is described in the regulation of tumour-induced angio/lymphangiogenesis promoted by Src in breast cancer and the combination of Src/ezrin might prove to be a beneficial prognostic/predictive biomarker for early-stage metastatic breast cancer.
Synthesis and evaluation of imidazole-dioxolane compounds as selective heme oxygenase inhibitors: effect of substituents at the 4-position of the dioxolane ring.
TL;DR: Several imidazole-dioxolane compounds were synthesized and evaluated as novel inhibitors of heme oxygenase (HO) and most of the compounds were found to be highly potent inhibitors of the stress-induced isozyme HO-1 and the constitutive isozymeHO-2, showing only moderate selectivity for HO-2.
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The Effects of Azole-Based Heme Oxygenase Inhibitors on Rat Cytochromes P450 2E1 and 3A1/2 and Human Cytochromes P450 3A4 and 2D6
Maaike Hum,Brian E. McLaughlin,Gheorghe Roman,Jason Z. Vlahakis,Walter A. Szarek,Kanji Nakatsu +5 more
TL;DR: To determine the effects of the QC-xx inhibitors on P450 enzyme activity, microsomal preparations of two rat P450 isoforms and two human P450 supersome isoforms were incubated with varying concentrations of HO inhibitor, and the activity was determined by spectrophotometric or fluorometric analysis.
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Recombinant truncated and microsomal heme oxygenase-1 and -2: differential sensitivity to inhibitors.
Dragic Vukomanovic,Brian McLaughlinB. McLaughlin,Mona N. Rahman,Jason Z. Vlahakis,Gheorghe Roman,Ryan A. Dercho,Robert T. Kinobe,Maaike Hum,James F. Brien,Zongchao JiaZ. Jia,Walter A. Szarek,Kanji Nakatsu +11 more
TL;DR: Recombinant truncated forms of heme oxygenase-1 and -2 were compared with their crude microsomal counterparts from brain and spleen tissue of adult male rats with respect to their inhibition by azole-based, nonporphyrin HO inhibitors.
10
Erratum to: “A novel role for ezrin in breast cancer angio/lymphangiogenesis”
Abdi Ghaffari,Victoria Hoskin,Alvin Szeto,Maaike Hum,Navid Liaghati,Kanji Nakatsu,David P. LeBrun,Yolanda Madarnas,Sandip SenGupta,Bruce E. Elliott +9 more
TL;DR: All authors have reviewed and approved the final version of this manuscript and agree to be accountable for all aspects of the work presented herein.