Zika virus infection and risk of Guillain-Barré syndrome: A meta-analysis.

The paper reviews recent progress in photodetectors, discussing vacuum-based detectors, semiconductor sensors, and gas-based detectors. The emphasis in this review is on the detection of low light levels, enhanced timing resolution, and spectral range of photon detectors, as well as the development of photosensors for extreme conditions, for operation in cryogenic and high radiation-level environments. 

Novel photon detectors

The GlueX experiment at Jefferson Laboratory aims to perform quantitative tests of non-perturbative QCD by studying the spectrum of light-quark mesons and baryons. A Detector of Internally Reflected Cherenkov light (DIRC) was installed to enhance the particle identification (PID) capability of the GlueX experiment by providing clean π/K separation up to 3.7 GeV/c momentum in the forward region (θ < 11°), which will allow the study of hybrid mesons decaying into kaon final states with significantly higher efficiency and purity. The new PID system is constructed with radiators from the decommissioned BaBar DIRC counter, combined with new compact photon cameras based on the SuperB FDIRC concept. The full system was successfully installed and commissioned with beam during 2019/2020. The initial PID performance of the system was evaluated and compared to one from Geant4 simulation.

/pdf/initial-performance-of-the-gluex-dirc-detector-3nryrl6h.pdf

Initial performance of the GlueX DIRC detector

Objective: To describe the demographic, clinical and laboratory features and, treatment and outcomes of Zika outbreak associated neurological syndromes. Methods: Zika outbreak associated neurological syndromes refer to specific neurological syndromes characterized by acute or sub-acute monophasic bilateral areflexic or hyporeflexic limb weakness and/or sensory impairment with or without cranial nerve, meningeal, myelopathic or encephalopathic abnormalities, with or without antecedent viral symptoms and without a more reasonable explanation during the Zika outbreak April to September 2016 at the Kingston Public Hospital (KPH). Medical records of men and women aged 12 years and over meeting these criteria were identified from intra-hospital records and reviewed for specific neurological syndrome classification based on clinical features, cerebrospinal fluid analysis, brain and spinal cord magnetic resonance imaging and neurophysiology. Results: Thirty-five cases were identified and 25 medical records reviewed. Three, eleven and seven patients met Brighton diagnostic criteria for Guillain-Barre syndrome (GBS) levels 1, 2 and 3, respectively. Other neurological syndromes were transverse myelitis (1), meningoencephalitis (2) and acute disseminated encephalomyelitis or [ADEM] (1). These four patients had additional findings typical of Guillain-Barre syndrome. Twenty-one reported antecedent viral symptoms, 12 required mechanical ventilation for respiratory failure and 23 received Intravenous Immunoglobulin (IVIg). Four of the 25 (16%) patients died. Conclusion: The current Zika outbreak in Jamaica has been accompanied by a spectrum of immunologically mediated acute neurological syndromes, the most common of which is GBS and appears associated with significant morbidity and mortality.

/pdf/zika-outbreak-associated-neurological-syndromes-in-jamaica-1m06687geu.pdf

Zika Outbreak Associated Neurological Syndromes in Jamaica

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Initial performance of the GlueX DIRC detector

Zika Outbreak Associated Neurological Syndromes in Jamaica