M. Sherr

TL;DR: It is found that CAG number alone accounted for 65%-71% of the variance in age of onset and the siblingship an individual belonged to accounted for 11%-19% of additional variance, adding to the previous evidence that there are familial modifiers of the age of dawn, independent of the CAGNumber.

TL;DR: Sample size calculations based on progression of the ADL and QNE in this study group revealed that a larger study group is necessary to detect any differences less than an almost complete halting of the disease.

TL;DR: Although Okuizumi and his associates and the authors' own group obtained the same result in Japanese subjects with PSP, an examination of the methodologies used in the two studies raises concerns with broader implications for the field of genetics in general.

TL;DR: It is concluded that change in caudate volume may be a useful outcome measure for assessing treatment effectiveness in both presymptomatic and symptomatic subjects.