M. Shea
Harvard University
7 Papers
244 Citations
M. Shea is an academic researcher from Harvard University. The author has contributed to research in topics: Bone remodeling & Osteoporosis. The author has an hindex of 7, co-authored 7 publications. Previous affiliations of M. Shea include Beth Israel Deaconess Medical Center.
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Papers
Effects of 4-amino-1-hydroxybutylidene bisphosphonate on bone biomechanics in rats.
Brian C. Toolan,M. Shea,Elizabeth R. Myers,R.E. Borchers,J.G. Seedor,H. Quartuccio,G. Rodan,Wilson C. Hayes +7 more
TL;DR: It is concluded that long‐term administration of AHBuBP in rats (started 4 months after ovariectomy) preserves the strength and area fraction of trabecular bone in the lumbar spine in a dose‐dependent manner, without evidence of detrimental effects upon the biomechanical or morphologic properties of cortical bone.
132
Comparison of alendronate and sodium fluoride effects on cancellous and cortical bone in minipigs. A one-year study.
TL;DR: There was an inverse correlation between bone turnover, estimated as the percentage of osteoid surface, and modulus, within the range of changes measured in this study, and these findings have relevant implications regarding the use of these agents for osteoporosis therapy.
Continuous alendronate treatment throughout growth, maturation, and aging in the rat results in increases in bone mass and mechanical properties
TL;DR: It is concluded that long-term ALN treatment preserves the structural and morphologic properties of both cortical and trabecular bone in rats and, with further study, may provide a valuable alternative to current therapy for the treatment of osteoporosis.
96
Effects of combined prostaglandin and alendronate treatment on the histomorphometry and biomechanical properties of bone in ovariectomized rats
D.B. Lauritzen,R. Balena,M. Shea,J.G. Seedor,A. Markatos,H.M. Le,Brian C. Toolan,Elizabeth R. Myers,Gideon A. Rodan,Wilson C. Hayes +9 more
TL;DR: Findings show that P GE2 stimulation of bone formation is not blocked by inhibition of bone resorption and that combined treatment with PGE2 and the bone resorsorption inhibitor ALN increased the mechanical strength of ovariectomized rat femoral shaft compared to nonovariECTomized animals.
84
•Journal Article
Preclinical evidence of normal bone with alendronate.
Wilson C. Hayes,M. Shea,Rodan Ga +2 more
TL;DR: Preclinical studies have established that the antiresorptive activity of alendronate results in the prevention of bone loss and the accretion of normal-quality bone.
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