OBJECTIVES: Considering the possibility that alcoholism induces gonadal dysfunction, the present work was designed to investigate the morphophysiology of rat testes submitted to experimental alcoholism. METHODS: Male Sprague-Dawley rats weighing 150 ± 5 gm were chronically given 40% ethanol solution at a dose of 3 g/kg body weight for 30 days. 3 H-thymidine autoradiographic investigations and histological studies were carried out to determine the proliferative activity and/or different stages of spermatogenesis in the seminiferous tubule cycle and Leydig cells. RESULTS: The 3 H-thymidine autoradigraphic investigation revealed that there was a signifi cant inhibition in the proliferative activity of the spermatogonia in all stages of the seminiferous tubule cycle in the alcoholtreated rats versus controls as indicated by the values of 3 H-labelling indices. The histological and numerical investigations indicated that the alcohol-treated rats presented testicular lesions including a signifi cant decrease in the diameter of the seminiferous tubules, the number of different germ cells in all stages of the seminiferous tubule cycle and the presence of degenerative germ cells. In addition, there was a signifi cant decrease in the number of Leydig cells. CONCLUSION: The present work suggests the deleterious effects of alcohol on the testes. These effects may be due to the effect of alcohol on the gonadotrophic cells of the pituitary gland and/or directly on the seminiferous tubules and Leydig cells.

Quantitative study on the effects of chronic ethanol administration on the testis of adult male rat.

/pdf/ronan-o-rahilly-1921-2018-a-personal-remembering-lu186adnz7.pdf

Ronan O'Rahilly 1921-2018: A Personal Remembering.

We describe a case of non-functioning pituitary adenoma in a 35-year-old woman with a prior history of fertility problems The patient had received clomiphen citrate and human chorionic gonadotrophin for 3 years Histological examination of the tumor revealed signet ring-like cell areas admixed with minor conventional round-polygonal neoplastic cells The two populations of tumor cells showed strong immunoreactivity for chromogranin and synaptophysin The clinicopathologic features and diagnostic difficulties of this rare entity are discussed

Signet ring-like cells in pituitary adenoma.

Here, we present a case of pituitary adenoma producing adrenocorticotropic hormone (ACTH) in a 19-year-old woman. The patient was admitted to neurosurgery clinic because of a headache and decreased visual acuity. Transsphenoidal resection was performed. Microscopic examination of the tumor revealed signet-ring-like cell areas intermixed with conventional pituitary adenoma cells. Both populations of tumor cells showed immunoreactivity for chromogranin, synaptophysin, and ACTH. To date, there have been 3 reports of pituitary adenoma with signet-ring-like changes. To our knowledge, this is the first case of ACTH-secreting pituitary adenoma with signet-ring-like cell changes. The clinical reflection of signet cells in pituitary adenoma is unclear. Accumulation of the similar cases and investigation of molecular background of them may lighten the importance of this morphologic variance.

ACTH-Cell Pituitary Adenoma With Signet Ring Cells: A Rare Case Report and Review of The Literature.

At 1-d postcastration of 2-mo-old rats, LH-immunoreactive (IR) cells were not hypertrophied in the female pituitary gland but a few LH-IR cells were hypertrophied in that of males. At 2-d postcastration, a few LH-IR cells were hypertrophied in the female pituitary gland and contained small cytoplasmic vacuoles in males. At 4-d postcastration, a few hypertrophied LH-IR cells contained a few small cytoplasmic vacuoles in the female pituitary gland and contained coalesced vacuoles in males. At 7-d postcastration, numerous hypertrophied LH-IR cells contained a few small cytoplasmic vacuoles in the female pituitary gland and contained coalesced vacuoles in males. At 14-d postcastration, a large number of hypertrophied LH-IR cells contained numerous cytoplasmic vacuoles in the female pituitary gland and had become arranged in irregular, interconnecting cords in males. At the electron microscopic level, cisternae of the rough endoplasmic reticulum (RER) were slightly dilated in non-hypertrophied gonadotrophs of the female pituitary gland but moderately dilated in hypertrophied gonadotrophs of males at 1-d postcastration. At 2-d postcastration, cisternae of the RER were slightly dilated in hypertrophied gonadotrophs of the female pituitary gland and moderately dilated in those of males. At 4-d postcastration, cisternae of the RER were moderately dilated in hypertrophied gonadotrophs of the female pituitary gland and had coalesced in those of males. At 7-d postcastration, cisternae of the RER remained moderately dilated in hypertrophied gonadotrophs of the female pituitary gland and had coalesced and markedly dilated in those of males. At 14-d postcastration, cisternae of the RER were similar to those in hypertrophied gonadotrophs of female and male pituitary glands at 7-d postcastration. Most of the secretory granules were small in size but a few large ones were also present in the cytoplasm of female and male hypertrophied gonadotrophs.

/pdf/lh-immunoreactivity-and-ultrastructural-changes-in-the-5b0hl80mwk.pdf

LH-Immunoreactivity and Ultrastructural Changes in the Pituitary Gland of Post-castrated Rats: Quantitative and Morphologic Studies

Histological and ultrastructural changes of hypophyseal gonadotropic cells of rats which received a 15% solution of ethyl alcohol for 6 months were studied. Light microscopy revealed hyperplasia and h

Castration cells in rat adenohypophysis after long-term alcohol consumption.

/pdf/guide-to-writing-articles-in-english-4rg8njhcb9.pdf

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Castration cells in rat adenohypophysis after long-term alcohol consumption.

Guide to Writing Articles in English