M. Ringel
University of Mainz
12 Papers
188 Citations
M. Ringel is an academic researcher from University of Mainz. The author has contributed to research in topics: Hepatocyte & Amniotic stem cells. The author has an hindex of 10, co-authored 11 publications.
Chat about Author
Papers
New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures.
Rolf Gebhardt,Jan G. Hengstler,Dieter Müller,R. Glöckner,Peter Buenning,Britta Laube,Eva Schmelzer,Martina Ullrich,Dietmar Utesch,Nicola J. Hewitt,M. Ringel,Beate Reder Hilz,Augustinus Bader,Angelika Langsch,Thomas Koose,Hans-Jörg Burger,Jochen Maas,Franz Oesch +17 more
TL;DR: Five in vitro systems with hepatocytes in suspension, perifusion culture systems, liver slices, co-culture systems of hepatocytes with intestinal bacteria, and 96-well plate bioreactors are discussed, which offer the possibility of high throughput and automatization.
275
Metabolic pathways of 4-bromo-2,5-dimethoxyphenethylamine (2C-B): analysis of phase I metabolism with hepatocytes of six species including human.
Helena Carmo,Jan G. Hengstler,D. de Boer,M. Ringel,Fernando Remião,Félix Carvalho,Eduarda Fernandes,Lesseps A. dos Reys,Franz Oesch,Maria de Lourdes Bastos +9 more
TL;DR: Comparing the toxic effects of 2C-B between hepatocytes of the six examined species the authors observed only minor interspecies differences, however, large inter-individual differences in susceptibility of hepatocytes from three human donors were observed.
82
Hepatocytes cultured in alginate microspheres: an optimized technique to study enzyme induction.
M. Ringel,M.-A. von Mach,Roberta Santos,Peter J. Feilen,Marc Brulport,Matthias Hermes,Alexander Bauer,Wiebke Schormann,Berno Tanner,Michael R. Schön,Franz Oesch,Jan G. Hengstler +11 more
TL;DR: The present study optimized an in vitro system with hepatocytes cultured in alginate microspheres that allows studies of enzyme induction with an improved sensitivity compared to existing systems and offers several technical advantages.
49
Comparative metabolism of the designer drug 4-methylthioamphetamine by hepatocytes from man, monkey, dog, rabbit, rat and mouse.
Helena Carmo,Jan G. Hengstler,D. de Boer,M. Ringel,Félix Carvalho,Eduarda Fernandes,Fernando Remião,Lesseps A. dos Reys,Franz Oesch,Maria de Lourdes Bastos +9 more
TL;DR: It is shown that 4-methylthiobenzoic acid is the main metabolite formed from 4-MTA by human hepatocytes and also by the hepatocytes of the other tested species except the rat, which suggests that rabbit hepatocytes are more resistant to 4- MTA than the other species, which may be due to the more extensive metabolism.
43
Size of pancreatic islets of Langerhans: a key parameter for viability after cryopreservation.
M.-A. von Mach,Josef Schlosser,Marcus Weiland,Peter J. Feilen,M. Ringel,Jan G. Hengstler,L. S. Weilemann,Jürgen Beyer,Peter H. Kann,Stephan Schneider +9 more
TL;DR: Large islets represented a highly susceptible population concerning damage due to cryopreservation, and different techniques of equilibration with the cryoprotectant resulted in significant changes of islet viability of medium islets, whereas small and large islets were unaffected.
38