M. Onno
University of Rennes
13 Papers
374 Citations
M. Onno is an academic researcher from University of Rennes. The author has contributed to research in topics: Human leukocyte antigen & Antigen. The author has an hindex of 13, co-authored 13 publications. Previous affiliations of M. Onno include University of Rennes 1 & French Institute of Health and Medical Research.
Chat about Author
Papers
The HLA-G gene is expressed at a low mRNA level in different human cells and tissues.
M. Onno,Thierry Guillaudeux,Laurence Amiot,I. Renard,Bernard Drenou,B Hirel,M Girr,Gilbert Semana,P. Le Bouteiller,Renée Fauchet +9 more
TL;DR: Northern blot and RT-PCR studies demonstrate that the HLA-G gene is transcribed in a variety of cells and adult tissues obtained from different individuals, as well as in fetal tissues, and a new hypothesis dealing with possible Hla-G function is proposed.
110
HLA-G class I gene expression in normal and malignant hematopoietic cells
TL;DR: It is suggested that the potential induction of HLA-G molecules in monocytic malignant cells following secretion of cytokines may constitute a factor of immune tolerance in patients.
79
Lung macrophages and dendritic cells express HLA-G molecules in pulmonary diseases
Céline Pangault,G Le Friec,Sylvie Caulet-Maugendre,H Léna,Laurence Amiot,Valérie Guilloux,M. Onno,Renée Fauchet +7 more
TL;DR: The expression of HLA-G in myelo-monocytic cells infiltrating lung pathologic tissues could alter antigenic presentation and contribute to decrease immune response efficiency, subsequently favoring the progression of tumoral or inflammatory processes.
78
Loss of HLA molecules in B lymphomas is associated with an aggressive clinical course
Laurence Amiot,M. Onno,Thierry Lamy,Charles Dauriac,Pierre-Yves Le Prise,Renée Fauchet,Bernard Drenou +6 more
TL;DR: Observations showed that total lack of class I or class II molecules is a rare event in NHL and is associated with a poor prognosis, which could support a role for specific autologous T cells in immune surveillance.
67
HLA-G protein expression is not induced during malignant transformation.
Céline Pangault,Laurence Amiot,Sylvie Caulet-Maugendre,Francis Brasseur,F. Burtin,Valérie Guilloux,Bernard Drenou,Renée Fauchet,M. Onno +8 more
TL;DR: HLA-G is not a marker of malignant cells but appears as a gene expressed in tumor-associated macrophages and dendritic cells, preferentially in those recruited in lung carcinomas, suggesting that specific environmental factors around lung tumors could be involved in the induction of HLA- G protein expression.
64