14 Papers
142 Citations
M. Noppe is an academic researcher from Johnson & Johnson Pharmaceutical Research and Development. The author has contributed to research in topics: Dosage form & Nanofiber. The author has an hindex of 12, co-authored 14 publications.
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Papers
Incorporation of drugs in an amorphous state into electrospun nanofibers composed of a water-insoluble, nonbiodegradable polymer.
Geert Verreck,Iksoo Chun,Joel Rosenblatt,Jef Peeters,Alex Van Dijck,J. Mensch,M. Noppe,Marcus E. Brewster +7 more
TL;DR: Electrostatic spinning was applied to the preparation of drug-laden nonbiodegradable nanofiber for potential use in topical drug administration and wound healing to assess whether these systems might be of interest as delivery systems for poorly water-soluble drugs.
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The use of human nasal in vitro cell systems during drug discovery and development.
TL;DR: The aim of this review is to give an overview of the information relevant for the development of a human nasal epithelial cell culture model useful during drug discovery and development.
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Self-assembling PEG-p(CL-co-TMC) copolymers for oral delivery of poorly water-soluble drugs: a case study with risperidone.
Louisa Ould-Ouali,M. Noppe,Xavier Langlois,B. Willems,Paula te Riele,Philip Timmerman,Marcus E. Brewster,Albertina Arien,Véronique Préat +8 more
TL;DR: The polymeric micelles of PEG-p(CL-co-TMC) seem to be a good candidate for oral drug delivery of poorly soluble drugs.
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Effect of the unstirred water layer on permeability enhancement by hydrophilic cyclodextrins.
TL;DR: It is suggested that hydrophilic cyclodextrins enhance flux when the UWL resistance significantly contributes to the overall barrier resistance.
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•Journal Article
The use of polymer-based electrospun nanofibers containing amorphous drug dispersions for the delivery of poorly water-soluble pharmaceuticals
Marcus E. Brewster,Geert Verreck,Iksoo Chun,Joel Rosenblatt,J. Mensch,A. Van Dijck,M. Noppe,Albertina Arien,M. Bruining,Jef Peeters +9 more
TL;DR: Electrostatic spinning was applied to the preparation of drug-laden nanofiber for potential use in oral and topical drug delivery and found that the non-woven fabrics derived from HPMC and containing itraconazole dissolved over a time course of minutes to hours depending on the formulation used as well as the drug/polymer ratios.
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