M Loss
Hochschule Hannover
31 Papers
219 Citations
M Loss is an academic researcher from Hochschule Hannover. The author has contributed to research in topics: Transplantation & Xenotransplantation. The author has an hindex of 10, co-authored 31 publications. Previous affiliations of M Loss include Hannover Medical School.
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Papers
Acute vascular rejection is associated with systemic complement activation in a pig-to-primate kidney xenograft model.
M Loss,B Vangerow,J Schmidtko,R Kunz,A Jalali,H. Arends,M. Przemeck,H. Rückholt,Martin Leuwer,F. J. Kaup,S Rensing,Emanuele Cozzi,David J. G. White,Jürgen Klempnauer,Monica E. Winkler +14 more
TL;DR: It is concluded that acute vascular xenograft rejection of porcine kidneys in cynomolgus monkeys is associated with classical pathway complement activation following binding of induced recipient anti‐porcine antibodies.
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Analysis of potential porcine endogenous retrovirus (PERV) transmission in a whole-organ xenotransplantation model without interfering microchimerism.
M Loss,Heiko Arends,Michael Winkler,M. Przemeck,Gustav Steinhoff,Susanne Rensing,F.J Kaup,Hans J. Hedrich,Monica E. Winkler,Ulrich Martin +9 more
TL;DR: A non-life-supporting pig-to-primate kidney xenotransplantation model was developed, and xenochimerism was found in tissue samples and partly even in peripheral blood leukocytes while the porcine kidneys were in situ, thus allowing analysis for possible PERV transmission.
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C1-Inhibitor for treatment of acute vascular xenograft rejection in cynomolgus recipients of h-DAF transgenic porcine kidneys.
B Vangerow,Jens Hecker,R Lorenz,M Loss,M. Przemeck,Richard Appiah,Jan Schmidtko,Arman Jalali,H Rueckoldt,Michael Winkler +9 more
TL;DR: It is concluded that AVR of h‐DAF transgenic porcine kidneys can be successfully treated by additional short‐term fluid phase complement inhibition.
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Influence of cold ischemia time, pretransplant anti-porcine antibodies, and donor/recipient size matching on hyperacute graft rejection after discordant porcine to cynomolgus kidney transplantation.
M Loss,R Kunz,M. Przemeck,J Schmidtko,H. Arends,A Jalali,R Lorenz,Siegfried Piepenbrock,Jürgen Klempnauer,Michael Winkler +9 more
TL;DR: Investigation of the influence of preoperative antiporcine antibody levels in the recipient, cold ischemia time, and donor organ weight on the onset of hyperacute rejection in the porcine to cynomolgus monkey setting indicates that by increasing the donor organ size and weight the frequency of the start of HAR can be at least reduced.
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