M Lindén
Karolinska Institutet
8 Papers
19 Citations
M Lindén is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Multiple sclerosis & Biology. The author has an hindex of 7, co-authored 8 publications.
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Papers
DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis
Lara Kular,Yun Liu,Yun Liu,Sabrina Ruhrmann,Galina Y. Zheleznyakova,Francesco Marabita,David Gomez-Cabrero,Tojo James,Ewoud Ewing,M Lindén,Bartosz Górnikiewicz,Shahin Aeinehband,Pernilla Stridh,Jenny Link,Till F. M. Andlauer,Till F. M. Andlauer,Christiane Gasperi,H. Wiendl,H. Wiendl,Frauke Zipp,Frauke Zipp,Ralf Gold,Ralf Gold,Björn Tackenberg,Björn Tackenberg,Frank Weber,Frank Weber,Bernhard Hemmer,Konstantin Strauch,Stefanie Heilmann-Heimbach,Rajesh Rawal,Ulf Schminke,Carsten Oliver Schmidt,Tim Kacprowski,Andre Franke,Matthias Laudes,Alexander T. Dilthey,Alexander T. Dilthey,Elisabeth Gulowsen Celius,Elisabeth Gulowsen Celius,Helle Bach Søndergaard,Jesper Tegnér,Jesper Tegnér,Hanne F. Harbo,Hanne F. Harbo,Annette Bang Oturai,Sigurgeir Olafsson,Hannes P. Eggertsson,Bjarni V. Halldorsson,Bjarni V. Halldorsson,Haukur Hjaltason,Haukur Hjaltason,Elias Olafsson,Elias Olafsson,Ingileif Jonsdottir,Ingileif Jonsdottir,Ingileif Jonsdottir,Kari Stefansson,Kari Stefansson,Tomas Olsson,Fredrik Piehl,Tomas J. Ekström,Ingrid Kockum,Andrew P. Feinberg,Maja Jagodic +64 more
TL;DR: The integrative approach provides insights into the molecular mechanisms of MS susceptibility and suggests putative therapeutic strategies targeting a methylation-mediated regulation of the major risk gene.
Epstein-Barr virus and multiple sclerosis: interaction with HLA.
Emilie Sundqvist,Peter Sundström,M Lindén,AK Hedström,Francesca Aloisi,Jan Hillert,Ingrid Kockum,Lars Alfredsson,Tomas Olsson +8 more
TL;DR: The observed interaction between HLA class I and II genotype and reactivity to EBV-related epitopes suggest that the mechanism through which HLA genes influence the risk of MS may, at least in part, involve the immune control of EBV infection.
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The Multiple Sclerosis Genomic Map: Role of peripheral immune cells and resident microglia in susceptibility
Nikolaos A. Patsopoulos,Sergio E. Baranzini,Adam Santaniello,Shoostari P,Chris Cotsapas,Wong G,Ashley Beecham,Tojo James,Replogle J,Ioannis S. Vlachos,Cristin McCabe,Tune H. Pers,Brandes A,Charles C. White,Brendan T. Keenan,Maria Cimpean,Winn P,Panteliadis I,Robbins A,Till F. M. Andlauer,Zarzycki O,Bénédicte Dubois,An Goris,Helle Bach Søndergaard,Finn Sellebjerg,Per Soelberg Sørensen,Henrik Ullum,Thoerner Lw,Janna Saarela,Rebeix Ic,Damotte,Bertrand Fontaine,Noel Lg,Mark Lathrop,Sandra Vukusik,Achim Berthele,Biberacher,Dorothea Buck,Christiane Gasperi,Christiane Graetz,Grummel,B. Hemmer,M.-M. Hoshi,Benjamin Knier,Thomas Korn,Christina M. Lill,Felix Luessi,Mark Mühlau,Frauke Zipp,Efthimios Dardiotis,Cristina Agliardi,Amoroso A,Nadia Barizzone,Benedetti M,Luisa Bernardinelli,Paola Cavalla,Ferdinando Clarelli,G. Comi,Daniele Cusi,Federica Esposito,Laura Ferrè,Daniela Galimberti,Clara Guaschino,Maurizio Leone,Martinelli,Moiola L,Marco Salvetti,Melissa Sorosina,Domizia Vecchio,Andrea Zauli,Silvia Santoro,Zuccalà M,Julia Y Mescheriakova,Duijn Cv,Steffan D. Bos,Elisabeth Gulowsen Celius,Anne Spurkland,Manuel Comabella,Xavier Montalban,Lars Alfredsson,Izaura Lima Bomfim,David Gomez-Cabrero,Jan Hillert,Maja Jagodic,M Lindén,Fredrik Piehl,Ilijas Jelcic,Roland Martin,Mireia Sospedra,Amie Baker,Maria Ban,Clive Hawkins,Hysi P,Seema Kalra,Fredrik Karpe,Jyoti Khadake,Genevieve Lachance,Molyneux P,Megan C Neville,J W Thorpe,Elizabeth M. Bradshaw,Stacy J. Caillier,Peter A. Calabresi,B. Cree,Anne H. Cross,Mary F. Davis,Bakker Pd,Silvia Delgado,Marieme Dembele,Keith R Edwards,Kathryn C. Fitzgerald,Frohlich I,Pierre-Antoine F. D. Gourraud,Jonathan L. Haines,Hakon Hakonarson,Dorlan J. Kimbrough,Noriko Isobe,Ioanna Konidari,Ellen Lathi,Marcus C. S. Lee,Taibo Li,An D,Zimmer A,Lo A,Lohith Madireddy,Clara P. Manrique,Mitja Mitrovic,Marta Olah,Ellis Patrick,Margaret A. Pericak-Vance,Laura Piccio,Cathy Schaefer,Howard L. Weiner,Kasper Lage,A Compston,David A. Hafler,Hanne F. Harbo,Stephen L. Hauser,Graeme J. Stewart,Sandra D'Alfonso,Giorgos M. Hadjigeorgiou,Bruce V. Taylor,Lisa F. Barcellos,David R. Booth,Rogier Q. Hintzen,Ingrid Kockum,Filippo Martinelli-Boneschi,Jacob L. McCauley,Jorge R. Oksenberg,Annette Bang Oturai,Stephen Sawcer,Ivinson A,Tommy Olsson,Phil De Jager,Murray L. Barclay,Laurent Peyrin-Biroulet,Mathias Chamaillard,Colombe J,Cottone M,Croft A,Renata D'Incà,Jonas Halfvarson,Hanigan K,Paul Henderson,Paul Henderson,Jean-Pierre Hugot,Jean-Pierre Hugot,Karban A,Nicholas A. Kennedy,Khan Ma,Marc Lémann,Arie Levine,Massey D,Monica Milla,Grant W. Montgomery,Evelyn Ng Sm,I. Oikonomou,Harald Peeters,Deborah D. Proctor,Jean-François Rahier,Roberts R,Paul Rutgeerts,Frank Seibold,Stronati L,Taylor Km,Törkvist L,Ublick K,Johan Van Limbergen,Gossum Av,Vatn Mh,Zhang H,Zhang W +191 more
TL;DR: While MS is most likely initially triggered by perturbation of peripheral immune responses the functional responses of microglia and other brain cells are also altered and may have a role in targeting an autoimmune process to the central nervous system.
IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis
Hannes Lindahl,André Ortlieb Guerreiro-Cacais,Sahl Khalid Bedri,Mathias Linnerbauer,M Lindén,Nada Abdelmagid,Karolina Tandre,Claire Hollins,Lorraine Irving,Colin P. Glover,Clare A. Jones,Lars Alfredsson,Lars Rönnblom,Ingrid Kockum,Mohsen Khademi,Maja Jagodic,Tomas Olsson +16 more
TL;DR: It is demonstrated that monocytes from carriers of the risk genotype of rs17066096 express more IL-22BP in vitro and cerebrospinal fluid levels of IL- 22BP correlate with MS lesion load on magnetic resonance imaging, suggesting a therapeutic potential of IL -22 in the context of MS.
Ethical criteria for the admission and management of patients in the icu under conditions of limited medical resources: A shared international proposal in view of the covid-19 pandemic
Vittoradolfo Tambone,Donald Boudreau,Massimo Ciccozzi,Karen Sanders,Laura Leondina Campanozzi,Jane Wathuta,Luciano Violante,Roberto Cauda,Carlo Petrini,Antonio Abbate,Rossana Alloni,Josepmaria Argemi,Josep Argemí Renom,Anna De Benedictis,Emilio García-Sánchez,Giampaolo Ghilardi,Janet P. Hafler,M Lindén,Alfredo Marcos,Andrea Onetti Muda,Marco Pandolfi,Thierry Pelaccia,Mario Picozzi,Ruben Oscar Revello,Giovanna Ricci,Robert Rohrbaugh,Patrizio Rossi,Ascanio Sirignano,Antonio Gioacchino Spagnolo,Trevor Stammers,Lourdes Velázquez,Evandro Agazzi,Mark R. Mercurio +32 more
TL;DR: Ethical Criteria for the Admission and Management of Patients in the ICU Under Conditions of Limited Medical Resources: A Shared International Proposal in View of the COVID-19 Pandemic.