11 Papers
438 Citations
M Le Meur is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Homeobox & Biology. The author has an hindex of 9, co-authored 11 publications.
Chat about Author
Papers
Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice.
TL;DR: It is reported that mice lacking the α6 integrin chain develop to birth, however, they die at birth with severe blistering of the skin and other epithelia, a phenotype reminiscent of the human disorder epidermolysis bullosa.
551
Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.
TL;DR: Results demonstrate that Otx2 is first required in the visceral endoderm for the induction, and subsequently in the neuroectodermfor the specification of forebrain and midbrain territories.
311
Conserved major histocompatibility complex class II boxes--X and Y--are transcriptional control elements and specifically bind nuclear proteins
TL;DR: Evidence is provided that the X and Y boxes play an important role in controlling transcription of the murine class II gene E kappa alpha, and proteins from nuclear extracts that bind specifically to the X or Y box are identified.
200
Axial skeleton homeosis and forelimb malformations in Hoxd-11 mutant mice.
TL;DR: It is found that Hoxd-11-/- mutant mice are viable and display homeotic transformations of their sacral vertebrae, while their forelimbs present abnormalities of some metacarpals and of the first row of carpal bones.
117
Cell autonomous and non-cell autonomous functions of Otx2 in patterning the rostral brain.
TL;DR: This study demonstrates that Otx2 is an important regulator of brain patterning and morphogenesis, through its regulation of candidate target genes such as Rpx/Hesx1, Wnt1, R-cadherin and ephrin-A2.
113