M.L. Garriott
Eli Lilly and Company
26 Papers
467 Citations
M.L. Garriott is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Micronucleus test & Micronucleus. The author has an hindex of 13, co-authored 26 publications.
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Papers
A protocol for the in vitro micronucleus test. II. Contributions to the validation of a protocol suitable for regulatory submissions from an examination of 10 chemicals with different mechanisms of action and different levels of activity.
TL;DR: This manuscript contributes to the validation of the protocol using 10 additional chemicals, and conclusions drawn from the developmental effort regarding the need for an extended exposure in the absence of metabolic activation, the number of cells to be counted, and the preferred statistical procedure for the assay are re-examined.
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A protocol for the in vitro micronucleus test
TL;DR: The investigation of several protocol parameters to assist with the development of a regulatory guideline for the IVM test indicate that cytochalasin B does not effect the outcome of the test, that the extended exposure treatment is not necessary, that counting 2000 cells is preferable to counting 1000, and that the data can be appropriately analyzed using a trend test.
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The in vivo rat micronucleus test: integration with a 14-day study.
TL;DR: The validation of a method for evaluating micronuclei in the bone marrow polychromatic erythrocytes of animals from this test is described to obtain additional information about the genotoxic potential of these compounds without incurring the cost of additional animals or the use of additional test article, which is often in limited supply.
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An evaluation of micronucleus induction in bone marrow and in hepatocytes isolated from collagenase perfused liver or from formalin-fixed liver using four-week-old rats treated with known clastogens.
Joseph W. Parton,M.L. Garriott +1 more
TL;DR: Results indicate that this modified liver micronucleus test, using 4‐wk‐old rats, offers an alternative to existing methods that use mitogens or partial hepatectomy to stimulate cell replication and provides additional flexibility by allowing the investigator to assess MN induction at a later time.
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Genotoxicity studies on the preemergence herbicide trifluralin.
M.L. Garriott,E. R. Adams,Gregory S. Probst,John L. Emmerson,T.J. Oberly,Delinda E.F. Kindig,Steven B. Neal,B.J. Bewsey,M.A. Rexroat +8 more
TL;DR: This paper reports the results of studies conducted within the Lily Research Laboratories and discusses additional studies with trifluralin that have been reported in the literature.
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