M. Isabel Calaza
Spanish National Research Council
14 Papers
77 Citations
M. Isabel Calaza is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Enantiopure drug & Enantioselective synthesis. The author has an hindex of 7, co-authored 14 publications. Previous affiliations of M. Isabel Calaza include Polytechnic University of Catalonia & University of Zaragoza.
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Papers
Stereoselective Synthesis of Quaternary Proline Analogues
TL;DR: This review describes available methods for the diastereoselective and asymmetric synthesis of quaternary prolines with the pyrrolidine moiety not embedded in a polycyclic frame.
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Access to the cis-fused stereoisomers of proline analogues containing an octahydroindole core
TL;DR: An overview of the synthetic methods developed to build all the cis-fused stereoisomers of octahydroindole-2-carboxylic acid and its α-methylated derivative in enantiomerically pure form is presented.
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Versatile methodology for the synthesis and α-functionalization of (2R,3aS,7aS)-octahydroindole-2-carboxylic acid
TL;DR: An improved strategy for the effective synthesis of enantiomerically pure (2R,3aS,7aS)-octahydroindole-2-carboxylic acid (Oic), based on the formation of a trichloromethyloxazolidinone derivative, has been developed.
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In silico molecular engineering for a targeted replacement in a tumor-homing peptide
David Zanuy,Alejandra Flores-Ortega,Ana I. Jiménez,M. Isabel Calaza,Carlos Cativiela,Ruth Nussinov,Erkki Ruoslahti,Carlos Alemán +7 more
TL;DR: Results suggest that replacement of Arg by (Pro)hArg in CREKA may be useful in providing resistance against proteolytic enzymes while retaining conformational features which are essential for tumor-homing activity.
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Practical access to the proline analogs (S,S,S)- and (R,R,R)-2-methyloctahydroindole-2-carboxylic acids by HPLC enantioseparation.
TL;DR: An efficient methodology for the preparation of the α-tetrasubstituted proline analog (S,S, S)-2-methyloctahydroindole-2-carboxylic acid and its enantiomer, (R,R, R)-(αMe)Oic, has been developed and multigram quantities of the target amino acids have been isolated in enantiomersically pure form and suitably protected for incorporation into peptides.
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