M. Gardner
University College London
2 Papers
9 Citations
M. Gardner is an academic researcher from University College London. The author has contributed to research in topics: Genome-wide association study & Missing heritability problem. The author has an hindex of 2, co-authored 2 publications.
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Papers
A Two-Stage Meta-Analysis Identifies Several New Loci for Parkinson's Disease
Vincent Plagnol,Mike A. Nalls,Jose Bras,Dena G. Hernandez,Dena G. Hernandez,M. Sharma,Una-Marie Sheerin,Mohamad Saad,Javier Simón-Sánchez,Claudia Schulte,Suzanne Lesage,Suzanne Lesage,Sigurlaug Sveinbjörnsdóttir,Philippe Amouyel,Philippe Amouyel,S. Arepalli,Roger A. Barker,C. Bellinguez,Yoav Ben-Shlomo,Henk W. Berendse,Daniela Berg,Kailash P. Bhatia,R. M. A. de Bie,Alessandro Biffi,Alessandro Biffi,B.R. Bloem,Zoltán Bochdanovits,Michael Bonin,Knut Brockmann,J. Brooks,David J. Burn,Gavin Charlesworth,Honglei Chen,Patrick F. Chinnery,Sean Chong,Carl E Clarke,Carl E Clarke,Mark R. Cookson,J. M. Cooper,Jean-Christophe Corvol,Carl Counsell,P. Damier,J. F. Dartigues,Panagiotis Deloukas,Günther Deuschl,David T. Dexter,K.D. van Dijk,Allissa Dillman,F. Durif,Alexandra Durr,Sarah Edkins,Jonathan R. Evans,Thomas Foltynie,Colin Freeman,Jianjun Gao,M. Gardner,J. R. Gibbs,J. R. Gibbs,A. Goate,Emma Gray,Rita Guerreiro,O. Gustafsson,Clare Elizabeth Harris,Garrett Hellenthal,J.J. van Hilten,Albert Hofman,Albert R. Hollenbeck,Janice L. Holton,Michele T.M. Hu,X. Huang,Heiko Huber,Gavin Hudson,Sarah E. Hunt,J. Huttenlocher,Thomas Illig,Palmi V. Jonsson,Cordelia Langford,Andrew J. Lees,Peter Lichtner,Patricia Limousin,Grisel Lopez,Delia Lorenz,Alisdair McNeill,C. Moorby,Matthew Moore,Huw R. Morris,Karen E. Morrison,Karen E. Morrison,Ese E. Mudanohwo,Sean S. O'Sullivan,J. P. Pearson,R. Pearson,Joel S. Perlmutter,H. Petursson,Matti Pirinen,Pierre Pollak,Bart Post,Simon C. Potter,Bernard Ravina,Tamas Revesz,O. Riess,Fernando Rivadeneira,Patrizia Rizzu,Mina Ryten,Stephen Sawcer,Peter Heutink,Nicholas W. Wood +106 more
TL;DR: Using a dataset of post-mortem brain samples assayed for gene expression and methylation, methylation and expression changes associated with PD risk variants in PARK16/1q32, GPNMB/7p15, and STX1B/16p11 loci are identified, suggesting potential molecular mechanisms and candidate genes at these risk loci.
Using genome-Wwide complex trait analysis to quantify 'missing heritability' in Parkinson's disease
Margaux F. Keller,Mohamad Saad,Jose Bras,F. Bettella,N. Nicolaou,Javier Simón-Sánchez,F. Mittag,F. Büchel,Manu Sharma,J. R. Gibbs,Claudia Schulte,Valentina Moskvina,Alexandra Durr,Peter Holmans,L. L. Kilarski,Rita Guerreiro,Dena G. Hernandez,Alexis Brice,P. Ylikotila,Hreinn Stefansson,K. Majamaa,Huw R. Morris,Nigel Williams,T. Gasser,Peter Heutink,Nicholas W. Wood,John Hardy,Maria Martinez,Andrew B. Singleton,Michael A. Nalls,Vincent Plagnol,UM Sheerin,Suzanne Lesage,Sigurlaug Sveinbjörnsdóttir,Sampath Arepalli,Roger A. Barker,Yoav Ben-Shlomo,Henk W. Berendse,Daniela Berg,Kailash P. Bhatia,R. M. A. de Bie,Alessandra Biffi,B.R. Bloem,Zoltán Bochdanovits,Michael Bonin,Knut Brockmann,Janet Brooks,David J. Burn,Gavin Charlesworth,Honglei Chen,Patrick F. Chinnery,Sean Chong,Carl E Clarke,M. R. Cookson,J. M. Cooper,Jean-Christophe Corvol,Carl Counsell,P. Damier,J. F. Dartigues,Panagiotis Deloukas,Günther Deuschl,David T. Dexter,K.D. van Dijk,Allissa Dillman,F. Durif,Sarah Edkins,Jonathan R. Evans,Thomas Foltynie,Jiali Gao,M. Gardner,A. Goate,Erin Gray,Omar Gustafsson,Clare Elizabeth Harris,J.J. van Hilten,Albert Hofman,Albert R. Hollenbeck,Janice L. Holton,Michele T.M. Hu,X. Huang,Heiko Huber,Gavin Hudson,Sarah E. Hunt,Johanna Huttenlocher,Thomas Illig,Palmi V. Jonsson,Jean-Charles Lambert,Cordelia Langford,Andrew J. Lees,Peter Lichtner,Patricia Limousin,Grisel Lopez,Delia Lorenz,Alisdair McNeill,C. Moorby,Matthew Moore,Karen E. Morrison,Ese E. Mudanohwo,Sean S. O'Sullivan,James A. Pearson,Joel S. Perlmutter,H. Petursson,Pierre Pollak,Bart Post,Simon C. Potter,Bernard Ravina,Tamas Revesz,O. Riess,Fernando Rivadeneira,Patrizia Rizzu,Mina Ryten,Stephen Sawcer,Anthony H.V. Schapira,Hans Scheffer,K. Shaw,Ira Shoulson,Ellen Sidransky,C Smith,C. C. A. Spencer,Stacy Steinberg,Joanne D. Stockton,A. Strange,Kevin Talbot,Caroline M. Tanner,Avazeh Tashakkori-Ghanbaria,François Tison,Daniah Trabzuni,Bryan J. Traynor,André G. Uitterlinden,Daan C. Velseboer,Marie Vidailhet,R. Walker,B.P.C. van de Warrenburg,M M Wickremaratchi,Caroline H. Williams-Gray,Sophie Winder-Rhodes,K. Stefansson,Peter Donnelly,Inês Barroso,Jenefer M. Blackwell,Elvira Bramon,Matthew A. Brown,Juan P. Casas,Aiden Corvin,Audrey Duncanson,Janusz Jankowski,Hugh S. Markus,Christopher G. Mathew,Colin N. A. Palmer,Robert Plomin,Anna Rautanen,Richard C. Trembath,Ananth C. Viswanathan,Céline Bellenguez,Colin Freeman,Garrett Hellenthal,Eleni Giannoulatou,Matti Pirinen,Richard G. Pearson,Z. Su,Damjan Vukcevic,R. Gwilliam,H. D. Blackburn,Suzannah Bumpstead,Serge Dronov,Matthew W. Gillman,Naomi Hammond,Alagurevathi Jayakumar,O. T. McCann,Jennifer Liddle,Radhi Ravindrarajah,Michelle Ricketts,Matthew Waller,Paul A. Weston,Sara Widaa,Pamela Whittaker,Mark I. McCarthy +176 more
- 01 Jan 2012
TL;DR: The results suggest that although GWASs are a useful tool in identifying the most common variants associated with complex disease, a great deal of common variants of small effect remain to be discovered.
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