M. Galasso
University Health Network
17 Papers
12 Citations
M. Galasso is an academic researcher from University Health Network. The author has contributed to research in topics: Transplantation & Lung transplantation. The author has an hindex of 5, co-authored 17 publications. Previous affiliations of M. Galasso include Toronto General Hospital.
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Papers
Prevention of viral transmission during lung transplantation with hepatitis C-viraemic donors: an open-label, single-centre, pilot trial.
Marcelo Cypel,Marcelo Cypel,Jordan J. Feld,M. Galasso,R. Ribeiro,N. Marks,Magdalena Kuczynski,Deepali Kumar,Ilona Bahinskaya,Vanderlei Salvador Bagnato,Cristina Kurachi,Arthur S. Slutsky,Jonathan C. Yeung,Jonathan C. Yeung,Laura Donahoe,Laura Donahoe,Marc de Perrot,Marc de Perrot,Kazuhiro Yasufuku,Kazuhiro Yasufuku,Andrew Pierre,Andrew Pierre,Matthew Binnie,Matthew Binnie,Cecilia Chaparro,Cecilia Chaparro,Tereza Martinu,Manyin Chen,Jussi Tikkanen,Chung-Wai Chow,Aman Sidhu,Thomas K. Waddell,Thomas K. Waddell,Shaf Keshavjee,Shaf Keshavjee,Lianne G. Singer,Atul Humar +36 more
TL;DR: This single centre, prospective, open-label, non-randomised trial aimed to assess the safety and efficacy of lung transplantation in humans from HCV-positive donors toHCV-negative recipients after application of ex-vivo lung perfusion (EVLP) plus ultraviolet C (UVC) perfusate irradiation.
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Inactivating hepatitis C virus in donor lungs using light therapies during normothermic ex vivo lung perfusion
M. Galasso,Jordan J. Feld,Y. Watanabe,M. Pipkin,C. Summers,Aadil Ali,R. Qaqish,Manyin Chen,R. Ribeiro,Khaled Ramadan,Layla Pires,Vanderlei Salvador Bagnato,Cristina Kurachi,Vera Cherepanov,Gray Moonen,A. Gazzalle,Thomas K. Waddell,Mingyao Liu,Shaf Keshavjee,Brian C. Wilson,Atul Humar,Marcelo Cypel +21 more
TL;DR: Physical viral clearance in combination with germicidal light-based therapies during normothermic ex-vivo Lung Perfusion (EVLP), a method for assessment and treatment of injured donor lungs, inactivates HCV virus in a short period of time and is shown to be safe and prevents HCV transmission in the pig model.
Static lung storage at 10°C maintains mitochondrial health and preserves donor organ function.
Aadil Ali,Aizhou Wang,R. Ribeiro,Erika L. Beroncal,Cristina Baciu,M. Galasso,B. Gomes,A. Mariscal,Olivia Hough,Edson Brambate,Etienne Abdelnour-Berchtold,V. Michaelsen,Yu Zhang,A. Gazzalle,Eddy Fan,Laurent Brochard,Laurent Brochard,Jonathan C. Yeung,Thomas K. Waddell,Mingyao Liu,Ana Cristina Andreazza,Shaf Keshavjee,Marcelo Cypel +22 more
TL;DR: In this article, cold static preservation on ice (~4°C) remains the clinical standard of donor organ preservation, however, mitochondrial injury develops during prolonged storage, which limits the extent of time th...
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Ex-vivo delivery of monoclonal antibody (Rituximab) to treat human donor lungs prior to transplantation.
Terrance J.Y. Ku,R. Ribeiro,Victor H Ferreira,M. Galasso,Shaf Keshavjee,Deepali Kumar,Marcelo Cypel,Atul Humar +7 more
TL;DR: The potential of EVLP as a platform to deliver monoclonal antibody therapies to treat donor lungs pretransplant with the goal of eliminating a latent virus responsible for considerable morbidity after lung transplantation is illustrated.
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Ex vivo treatment of cytomegalovirus in human donor lungs using a novel chemokine-based immunotoxin.
R. Ribeiro,Terrance Ku,Aizhou Wang,Layla Pires,Victor H Ferreira,V. Michaelsen,Aadil Ali,M. Galasso,S. Moshkelgosha,A. Gazzalle,Mads G. Jeppesen,Mette M. Rosenkilde,Mingyao Liu,Lianne G. Singer,Deepali Kumar,Shaf Keshavjee,John Sinclair,Thomas N Kledal,Atul Humar,Marcelo Cypel +19 more
TL;DR: In this article, an immunotoxin (F49A-FTP) was used to target and kill latent HCMV from donor lungs using ex-vivo lung perfusion (EVLP).
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