https://n.neurology.org/content/neurology/60/6/1055.1.full.pdf

Severe neurologic complications after hematopoietic stem cell transplantation in children

Lung Function and Late Pulmonary Complications Among Survivors of Hematopoietic Stem Cell Transplantation During Childhood

Veno-occlusive disease of the liver after allogeneic bone marrow transplantation in children with hematologic malignancies: incidence,onset time and risk factors(小児造血器腫瘍に対する同種骨髄移植後の肝中心静脈閉塞症: 発症頻度、発症時期、危険因子について)

Sperm cryopreservation before cancer treatment - 7 yearexperience.

Hematopoietic stem cell transplantation, despite being a curative treatment for various pediatric disorders, is associated with significant acute and chronic complications. This retrospective review of 196 hematopoietic stem cell transplantation episodes (144 allogeneic, 52 autologous) performed in a tertiary pediatric unit focused on neurological symptoms and complications occurred from the start of conditioning to within 3 years of transplantation. Indications for transplantation included both benign and malignant diseases. For episodes involving allogeneic transplantation, 42% of donors were matched-unrelated, 19% were matched-sibling, and 12% were haploidentical. Neurological complications developed in 17% of all hematopoietic stem cell transplantation episodes. Tumors of central nervous system and leukemia or lymphoma were two indications reported to have higher incidence of 42% and 21%, respectively. The occurrence of neurological complications was significantly associated with primary diagnosis (p = 0.01), central nervous system involvement by underlying disease (p = 0.001), and radiation-based conditioning (p = 0.018). Upon multivariate analysis, central nervous system involvement by underlying disease remained to be the only significant factor (p = 0.019), while radiation-based containing conditioning (p = 0.029) is revealed to be associated when considering allogeneic transplantation alone. Pre-transplant central nervous system–directed treatment, allogeneic versus autologous donor, stem cell source, donor type, busulfan use, and cyclosporin use were not significantly associated with neurological complications. Patients with neurological complications were also found to have an inferior 2-year overall survival (53.9% ± 8.8% versus 63.8% ± 4.2%; p = 0.016). Neurological complications were common in pediatric hematopoietic stem cell transplantation and were associated with adverse outcome; non-radiation containing conditioning regimens might be beneficial in mitigating the risk of such complications.

Neurological Complications In Chinese Children Undergoing Hematopoietic Stem Cell Transplantation (hsct)

Children surviving after haematopoietic SCT (HSCT) are a growing population that need to keep their health status under control. They may experience early and late complications that are related to transplant procedures and to treatments administered before HSCT. Monitoring transplant-related complications is mandatory, especially during the child's growth. The purpose of this report is to define preassessment in patients who are candidates for HSCT to identify any pretransplant, comorbid conditions and to individually tailor the HSCT procedure, whenever possible.

Assessing the risk of transplant-related complications and individually tailoring the HSCT procedure in children and adolescents--is it possible?

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Assessing the risk of transplant-related complications and individually tailoring the HSCT procedure in children and adolescents--is it possible?