https://www.ajkd.org/article/S0272-6386(96)90045-1/pdf

Endothelin in Organ Transplantation

/pdf/immunomodulators-interleukins-interferons-and-the-okt3-2ztokm60w7.pdf

Immunomodulators: interleukins, interferons, and the OKT3 monoclonal antibody

OKT3 is a murine monoclonal antibody recognizing the CD3 complex closely associated with the antigen receptor of mature T cells (TCR) [1]. T lymphocytes are of paramount importance in allograft rejection, and OKT3 has proved very efficient in both prevention and treatment of allograft rejection [2–5]. The immunosuppressive properties of OKT3 are related to its ability to deplete CD3 4- cells from the circulation, to induce the internalization of CD3-TCR complexes (modulation), and to sterically inhibit residual CD3-TCR complexes [6]. Before exerting its immunosuppressive effects, OKT3 induces a transient activation of leucocytes. The ability of OKT3 to induce multivalent cross-linking of both the T cell-receptor/CD3 complex and the monocyte Fc receptor results in T cell and monocyte activation [7].

OKT3 Nephrotoxicity: From acute tubular necrosis to hemolytic uremic syndrome

First dose OKT3-induced release of endothelin in renal transplant recipients

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First dose OKT3-induced release of endothelin in renal transplant recipients