M. Cro

TL;DR: The results show that a dosage of 40 mg twice daily (every 12 hrs) is accompanied by a significantly longer half-life and mean residence time (MRT) than a single 80 mg dose, even though the latter causes a higher concentration peak (Cmax).

TL;DR: Patients suffering from insulin-dependent type 1 diabetes mellitus often complain of eye discomfort and have a higher glucose content in tears than control subjects of the same age and sex, and the increase in glucose could in some way alter the balance between the various components of tear film, thus reducing its stability.

TL;DR: In this article, the authors present a viscoelastic composition, methods of use and a related device, where the visco-elastic comprises water, a minimum of about 0.01% w/v and a maximum of about 10% w /v of hyaluronic acid or a salt thereof.

Abstract: Patients suffering from insulin-dependent type 1 diabetes mellitus often complain of eye discomfort and have a higher glucose content in tears than control subjects of the same age and sex.1,2 In addition, the glucose content is not correlated with glycemia and HbA1C but is inversely correlated with the break-up time for corneal tear film (BUT). Presumably, the increase in glucose could in some way alter the balance between the various components of tear film, thus reducing its stability.