M. Coleman
Repatriation General Hospital
14 Papers
73 Citations
M. Coleman is an academic researcher from Repatriation General Hospital. The author has contributed to research in topics: Rheumatoid arthritis & Synovial membrane. The author has an hindex of 9, co-authored 14 publications.
Chat about Author
Papers
•Journal Article
Synovial membrane inflammation and cytokine production in patients with early osteoarthritis.
TL;DR: Chronic inflammatory changes with production of proinflammatory cytokines are a feature of synovial membranes from patients with early OA, with the most severe changes seen in patients at the time of joint replacement surgery resembling those seen in rheumatoid arthritis.
566
Pathogenic mechanisms in the rheumatoid nodule: Comparison of proinflammatory cytokine production and cell adhesion molecule expression in rheumatoid nodules and synovial membranes from the same patient
R. Wikaningrum,John Highton,A. Parker,M. Coleman,Paul A. Hessian,Peter Roberts-Thomson,Michael Ahern,Malcolm D. Smith +7 more
TL;DR: The presence of similar proinflammatory cytokines and cell adhesion molecules in the rheumatoid nodule and synovial membrane suggests that similar pathogenic processes result in the chronic inflammation and tissue destruction in these lesions.
68
Treatment‐induced remission in rheumatoid arthritis patients is characterized by a reduction in macrophage content of synovial biopsies
Malcolm D. Smith,Maarten C. Kraan,John P. Slavotinek,Virginia Au,H. Weedon,A. Parker,M. Coleman,Peter Roberts-Thomson,Michael Ahern +8 more
TL;DR: Remission in RA patients is characterized by a predominant reduction in macrophage content of the synovial membrane, suggesting that current DMARDs may target this cell and its inflammatory mediators.
57
•Journal Article
Variability in cytokine and cell adhesion molecule staining in arthroscopic synovial biopsies: quantification using color video image analysis.
P P Youssef,Sophie Triantafillou,A. Parker,M. Coleman,Peter Roberts-Thomson,Michael Ahern,Malcolm D. Smith +6 more
TL;DR: The variability in cytokine and cell adhesion molecule staining within any single biopsy usually reflects the variability between biopsies taken from different sites in the same rheumatoid joint when the immunostaining is quantified using color video image analysis.
48
Glomerular basement membrane abnormalities associated with apparently idiopathic hematuria: Ultrastructural morphometric analysis
TL;DR: The GBM measurements confirmed the subjective impression of membrane abnormality, usually attenuation, as the principal finding in this group of hematuric patients, and morphometric analysis may reveal subtle changes of GBM thickness missed by subjective assessment.
38