M. Carmen Thomas
Spanish National Research Council
52 Papers
421 Citations
M. Carmen Thomas is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Cytotoxic T cell & Trypanosoma cruzi. The author has an hindex of 17, co-authored 52 publications.
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Papers
Biological markers for evaluating therapeutic efficacy in Chagas disease, a systematic review
María-Jesús Pinazo,M. Carmen Thomas,Jacqueline Búa,Alina Elizabeth Perrone,Alejandro G. Schijman,Rodolfo-Jorge Viotti,Janine-M Ramsey,Isabela Ribeiro,Sergio Sosa-Estani,Manuel-Carlos López,Joaquim Gascon +10 more
TL;DR: A systematic review of current evidence regarding molecules which are potential biomarkers for therapeutic response has been conducted using quality assessment and target responses as primary criteria, providing a panorama of the cumulative evidence and specific needs for development of a battery of complementary biomarkers.
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Inhibitory Receptor Expression on CD8+ T Cells Is Linked to Functional Responses against Trypanosoma cruzi Antigens in Chronic Chagasic Patients
Paola Lasso,Jose Mateus,Paula Pavia,Fernando Rosas,Nubia Roa,M. Carmen Thomas,Manuel Carlos López,John Mario González,Concepción J. Puerta,Adriana Cuéllar +9 more
TL;DR: It is suggested that during the course of Chagas disease, CD8+ T cells undergo a gradual loss of function characterized by impaired cytokine production, the presence of advanced differentiation, and increased inhibitory receptor coexpression.
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The genetic immunization with paraflagellar rod protein-2 fused to the HSP70 confers protection against late Trypanosoma cruzi infection.
TL;DR: Investigation in mice found that immunization with the PFR2-HSP70 chimeric gene provided a protective response against a T. cruzi experimental infection.
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Identification of an hepatitis delta virus-like ribozyme at the mRNA 5′-end of the L1Tc retrotransposon from Trypanosoma cruzi
Francisco J. Sanchez-Luque,Manuel Carlos López,Francisco Macías,Carlos Alonso,M. Carmen Thomas +4 more
TL;DR: The data presented show that L1TcRz has a co-transcriptional function and indicates that the kinetics of the self-cleaving, in a magnesium-dependent reaction, fits to a two-phase decay curve.
The immunization of A2/Kb transgenic mice with the KMP11-HSP70 fusion protein induces CTL response against human cells expressing the T. cruzi KMP11 antigen: identification of A2-restricted epitopes
TL;DR: The fact that the CTL lines induced in B6-A2/K(b) mice recognize human cells expressing KMP11 protein, indicates that the K MP11 antigen fused to HSP70 could be a good candidate for the induction of immunoprotective cytotoxic responses against T. cruzi natural infection.
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