M. C. Morelli
Astra
5 Papers
105 Citations
M. C. Morelli is an academic researcher from Astra. The author has contributed to research in topics: Budesonide & Eosinophil. The author has an hindex of 5, co-authored 5 publications.
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Papers
Postallergen inhaled budesonide reduces late asthmatic response and inhibits the associated increase of airway responsiveness to methacholine in asthmatics.
P.L. Paggiaro,Fl Dente,M. C. Morelli,L Bancalari,A Di Franco,D Giannini,Barbara Vagaggini,Elena Bacci,Leonardo M. Fabbri,Carlo Giuntini +9 more
TL;DR: It is suggested that inhaled budesonide may not only prevent but also reduce the late asthmatic response induced by allergen and that it might also be considered in the treatment of exacerbation of asthma.
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Comparison between eosinophilic markers in induced sputum and blood in asthmatic patients
Elena Bacci,Silvana Cianchetti,L Ruocco,Ml Bartoli,S Carnevali,Fl Dente,Di Franco A,D Giannini,P Macchioni,Barbara Vagaggini,M. C. Morelli,Pierluigi Paggiaro +11 more
TL;DR: The analysis of induced sputum has been proposed as a safe, non‐invasive tool in the study of airway inflammation in asthma and its usefulness and safety are widely recognized.
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Eosinophil locomotion and the release of IL-3 and IL-5 by allergen-stimulated mononuclear cells are effectively downregulated in vitro by budesonide
TL;DR: Treatment of aliergic asthma with inhaled corticosteroids, such as budesonide (BDN), results in downregulation of T‐cell activation and of eosinophil recruitment.
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Effects of “systemic” budesonide concentrations on in vitro allergen‐induced activation of blood mononuclear cells isolated from asthmatic patients
TL;DR: The blood concentrations of budesonide, after drug inhalation, may exert some anti‐inflammatory effect, downregulating both “local” (through the bronchial circulation) and “systemic” allergen‐specific immune reactions.
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Budesonide down-regulates eosinophil locomotion but has no effects on ECP release or on H2O2 production.
Sabina Lantero,S. Oddera,Michela Silvestri,R. Gonzalez Rodriguez,M. C. Morelli,Giovanni A. Rossi +5 more
TL;DR: Concentrations of budesonide similar to those obtained in vivo are effective in inhibiting eosinophil locomotion but not in down-regulating the release of reactive oxygen species and granule-associated proteins.
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