M.-C. Coene
Janssen Pharmaceutica
32 Papers
956 Citations
M.-C. Coene is an academic researcher from Janssen Pharmaceutica. The author has contributed to research in topics: Ketoconazole & Itraconazole. The author has an hindex of 21, co-authored 32 publications. Previous affiliations of M.-C. Coene include Janssen-Cilag.
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Papers
Effect of hypercholesterolemia on vascular reactivity in the rabbit. I. Endothelium-dependent and endothelium-independent contractions and relaxations in isolated arteries of control and hypercholesterolemic rabbits.
TL;DR: In arteries obtained from hypercholesterolemic rabbits, the contractions caused by serotonergic mechanisms tend to be augmented, while those to α-adrenergic activation are decreased, and the endothelium-independent relaxations are modified only in the more severely affected arteries.
555
•Journal Article
Effects of cytochrome P-450 inhibitors on the in vivo metabolism of all-trans-retinoic acid in rats.
TL;DR: In vivo inhibition of the P-450 pathway not only increased the biological half-life of exogenously administered RA, but also enhanced the endogenous plasma level of this vitamin A derivative.
150
Interaction of azole derivatives with cytochrome P‐450 isozymes in yeast, fungi, plants and mammalian cells
Hugo Vanden Bossche,Patrick Marichal,J. Gorrens,D. Bellens,Hugo Verhoeven,M.-C. Coene,W. Lauwers,Paul A. J. Janssen +7 more
TL;DR: Yeast and plant membranes contain rather small amounts of cytochrome P–450 as compared with membrane fractions prepared from bovine adrenal cortex, piglet testis and rabbit liver, which suggests that the azole-induced ergosterol depletion might represent a greater contribution to their fungicidal activity than the accumulation of 14α-methylsterols.
128
•Journal Article
Liarozole, an inhibitor of retinoic acid metabolism, exerts retinoid-mimetic effects in vivo.
J. Van Wauwe,G. Van Nyen,M.-C. Coene,P. Stoppie,W. Cools,J. Goossens,P. Borghgraef,P. A. J. Janssen +7 more
TL;DR: Findings indicate that liarozole, an inhibitor of RA metabolism and RA produce similar morphologic and biochemical effects on the differentiation process of rat vaginal epithelium.
123
Biochemical approaches to selective antifungal activity. Focus on azole antifungals.
H. Vanden Bossche,Patrick Marichal,J. Gorrens,M.-C. Coene,G. Willemsens,D. Bellens,I. Roels,Henri Moereels,P. A. J. Janssen +8 more
TL;DR: Azole antifungals inhibit in fungal cells the 14α‐demethylation of lanosterol or 24–methylenedihydro‐lanosterol.
116