M Benhamou
National Institutes of Health
5 Papers
444 Citations
M Benhamou is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Receptor tyrosine kinase & Tyrosine phosphorylation. The author has an hindex of 5, co-authored 5 publications.
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Papers
Protein-tyrosine kinase p72syk in high affinity IgE receptor signaling. Identification as a component of pp72 and association with the receptor gamma chain after receptor aggregation.
TL;DR: Results demonstrate that pp72 is composed of several phosphoproteins and identify p72syk as one component of pp72, and indicate that the interaction between p72Syk-related tyrosine kinases and zeta-related proteins could play an important role in signal transduction.
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Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release.
TL;DR: Tyrosine phosphorylation is an early signal following Fc epsilon RI aggregation, independent of the exocytotic process itself, leading to histamine release.
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High-affinity IgE receptor-mediated stimulation of rat basophilic leukemia (RBL-2H3) cells induces early and late protein-tyrosine phosphorylations.
TL;DR: It is concluded that tyrosine phosphorylation of pp72 is associated with the early steps of IgE receptor-generated signaling, whereas pp110 tyrosin phosphorylated protein occurs secondary to calcium influx and protein kinase C activation.
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Fc epsilon RI-induced protein tyrosine phosphorylation of pp72 in rat basophilic leukemia cells (RBL-2H3). Evidence for a novel signal transduction pathway unrelated to G protein activation and phosphatidylinositol hydrolysis.
TL;DR: Results suggest that pp72 tyrosine phosphorylation represents a distinct, independent signaling pathway induced specifically by aggregation of the Fc epsilon RI.
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Activation of protein tyrosine kinase p72syk by Fc epsilon RI aggregation in rat basophilic leukemia cells. p72syk is a minor component but the major protein tyrosine kinase of pp72.
K Minoguchi,M Benhamou,William D. Swaim,Yuko Kawakami,Toshiaki Kawakami,Reuben P. Siraganian +5 more
TL;DR: The results demonstrate the heterogeneous nature of the pp72 and that p72syk is activated after Fc epsilon RI aggregation and is identified as p75HS1 (SPY75).
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