Chemotherapy is the standard initial treatment for patients with small cell lung cancer (SCLC), and combination chemotherapy can prolong the lives of patients with non-small cell lung cancer (NSCLC) [1,2]. Despite these developments, most patients develop metastatic disease, and lung cancer remains the leading cause of death from cancer [3]. Over the past five years, a number of new agents with activity against lung cancer have been identified, offering the potential for improved control of this disease. A number of these drugs have novel mechanisms of action. Additionally, the understanding of the pharmacokinetics of ‘older’ agents has expanded, resulting in the more effective use of the available chemotherapeutic drugs. At the same time, we have also learned that many new agents have insufficient antitumor activity against lung cancer to warrant further development. Agents identified between 1988 and 1993 with potential usefulness in lung cancer patients are presented in table 1 and discussed in detail below.

New antineoplastic agents in lung cancer 1988-1993.

Platino+vindesine(PV) vs PV+lonidamine(L) in non small cell lung cancer(NSCLC). Preliminary results of a randomized study

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Platino+vindesine(PV) vs PV+lonidamine(L) in non small cell lung cancer(NSCLC). Preliminary results of a randomized study