M. Audero
4 Papers
M. Audero is an academic researcher. The author has contributed to research in topics: Cancer research & Medicine. The author has an hindex of 2, co-authored 3 publications.
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Papers
Ca2+ Signalling and Hypoxia/Acidic Tumour Microenvironment Interplay in Tumour Progression
TL;DR: In this paper , the authors present an up-to-date and critical view on Ca2+ permeable ion channels, with a major focus on TRPs, SOCs and PIEZO channels, which are modulated by tumour hypoxia and acidosis.
TRPM8-Rap1A Interaction Sites as Critical Determinants for Adhesion and Migration of Prostate and Other Epithelial Cancer Cells
Giorgia Chinigò,Guillaume Grolez,M. Audero,Alexandre Bokhobza,Michela Bernardini,Julien Cicero,Robert-Alain Toillon,Quentin Bailleul,Luca Visentin,Federico Alessandro Ruffinatti,Guillaume Brysbaert,Marc F. Lensink,Jérôme de Ruyck,Anna Rita Cantelmo,Alessandra Fiorio Pla,Dimitra Gkika +15 more
TL;DR: The present work elucidates the molecular mechanism through which TRPM8 exerts its inhibitory effect on cell migration and adhesion and reveals a novel facet of PCa motility control via direct protein-protein interaction (PPI) of the channel with the small GTPase Rap1A.
Acidic Growth Conditions Promote Epithelial-to-Mesenchymal Transition to Select More Aggressive PDAC Cell Phenotypes In Vitro
M. Audero,Federico Alessandro Ruffinatti,Thorsten Loeck,Maya Yassine,Giorgia Chinigò,Antoine Folcher,Valerio Farfariello,Albrecht Schwab,Stephan J. Reshkin,Rosa Angela Cardone,Natalia Prevarskaya,Alessandra Fiorio Pla +11 more
TL;DR: In this paper , the authors investigated the role of acidosis in the invasive process of pancreatic Ductal Adenocarcinoma (PDAC) cells and found that short acidic treatment limits growth, adhesion, invasion, and viability of PDAC cells.
Tumor Microenvironment Modulates Invadopodia Activity of Non-Selected and Acid-Selected Pancreatic Cancer Cells and Its Sensitivity to Gemcitabine and C18-Gemcitabine
T. M. A. Carvalho,M. Audero,Maria Raffaella Greco,Marilena Ardone,Teresa Maggi,Rosanna Mallamaci,Barbara Rolando,S. Arpicco,Federico Alessandro Ruffinatti,Alessandra Fiorio Pla,Natalia Prevarskaya,Tomas Koltai,Stephan J. Reshkin,Rosa Angela Cardone +13 more
TL;DR: C18 has higher cytotoxic and anti-invadopodia activity than GEM in all culture conditions and especially in acid and hypoxic environments, proposing C18 as a more effective approach to conventional GEM in developing new therapeutic strategies overcoming PDAC chemoresistance.