M Ableitner
Max Planck Society
4 Papers
15 Citations
M Ableitner is an academic researcher from Max Planck Society. The author has contributed to research in topics: Corticotropin-releasing hormone & Internal medicine. The author has an hindex of 4, co-authored 4 publications.
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Papers
Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior
Ailing Lu,M. A. Steiner,Nigel Whittle,Annette M. Vogl,S. M. Walser,M Ableitner,Damian Refojo,Marc Ekker,John L.R. Rubenstein,Günter K. Stalla,Nicolas Singewald,Florian Holsboer,Carsten T. Wotjak,Wolfgang Wurst,Jan M. Deussing +14 more
TL;DR: Enhanced noradrenergic activity was identified as potential molecular mechanism underlying increased active stress-coping behavior observed in these animals and may serve as animal models for stress-elicited pathologies and treatments that target the central CRH system.
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Assessing Behavioural Effects of Chronic HPA Axis Activation Using Conditional CRH-Overexpressing Mice
Nina Dedic,Chadi Touma,Cristoph P. Romanowski,Marcel Schieven,Claudia Kühne,M Ableitner,Ailing Lu,Florian Holsboer,Wolfgang Wurst,Mayumi Kimura,Jan M. Deussing +10 more
TL;DR: The generated mouse lines represent valuable animal models to study the consequences of chronic CRH overproduction and HPA axis activation and suggest that central CRH hyperdrive on its own or in combination with elevated glucocorticoids is responsible for the increase in anxiety-related behaviour.
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Conditional CRH overexpressing mice: an animal model for stress-elicited pathologies and treatments that target the central CRH system.
Ailing Lu,M. A. Steiner,Nigel Whittle,Annette M. Vogl,S. M. Walser,M Ableitner,Damian Refojo,Marc Ekker,John L.R. Rubenstein,Günter K. Stalla,Nicolas Singewald,Florian Holsboer,Carsten T. Wotjak,Wolfgang Wurst,Jan M. Deussing +14 more
TL;DR: Conditional CRH overexpressing mice are used as an animal model for stress-elicited pathologies and treatments that target the central CRH system.
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Cell type-specific modifications of corticotropin-releasing factor (CRF) and its type 1 receptor (CRF1) on startle behavior and sensorimotor gating.
Elizabeth I. Flandreau,Victoria B. Risbrough,Ailing Lu,M Ableitner,Mark A. Geyer,Florian Holsboer,Jan M. Deussing +6 more
TL;DR: The data indicate that the effects of CRF activation on startle behavior utilize an extensive neural circuit that includes both forebrain and non-forebrain regions, and suggest that the neural source of increased CRF release determines the startle phenotype elicited.
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