https://www.clearsightclearmind.com/files/Alavizadeh_2014.pdf

Bioactivity assessment and toxicity of crocin: A comprehensive review

Neuroinflammation is an important feature in the pathogenesis and progression of neurodegenerative diseases such as Alzheimer´s disease (AD), Parkinson´s disease (PD), frontotemporal dementia and amyotrophic lateral sclerosis. Based on current knowledge in the field, suggesting that targeting peripheral inflammation could be a promising additional treatment/prevention approach for neurodegenerative diseases, drugs and natural products with anti-inflammatory properties have been evaluated in animal models of neuroinflammation and neurodegeneration. In this review, we provide an extensive analysis of one of the most important and widely-used animal models of peripherally induced neuroinflammation and neurodegeneration - lipopolysaccharide (LPS)-treated mice, and address the data reproducibility in published research. We also summarize briefly basic features of various natural products, nutraceuticals, with known anti-inflammatory effects and present an overview of data on their therapeutic potential for reducing neuroinflammation in LPS-treated mice.

LPS-induced Murine Neuroinflammation Model: Main Features and Suitability for Pre-clinical Assessment of Nutraceuticals.

Pinocembrin (5,7-dihydroxyflavanone) is one of the primary flavonoids isolated from the variety of plants, mainly from Pinus heartwood, Eucalyptus, Populus, Euphorbia, and Sparattosperma leucanthum, in the diverse flora and purified by various chromatographic techniques. Pinocembrin is a major flavonoid molecule incorporated as multifunctional in the pharmaceutical industry. Its vast range of pharmacological activities has been well researched including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities. In addition, pinocembrin can be used as neuroprotective against cerebral ischemic injury with a wide therapeutic time window, which may be attributed to its antiexcitotoxic effects. Pinocembrin exhibits pharmacological effects on almost all systems, and our aim is to review the pharmacological and therapeutic applications of pinocembrin with specific emphasis on mechanisms of actions. The design of new drugs based on the pharmacological effects of pinocembrin could be beneficial. This review suggests that pinocembrin is a potentially promising pharmacological candidate, but additional studies and clinical trials are required to determine its specific intracellular sites of action and derivative targets in order to fully understand the mechanism of its anti-inflammatory, anticancer, and apoptotic effects to further validate its medical applications.

/pdf/pinocembrin-a-novel-natural-compound-with-versatile-2lqmieqto7.pdf

Pinocembrin: A Novel Natural Compound with Versatile Pharmacological and Biological Activities

Review on Alzheimer's disease: Inhibition of amyloid beta and tau tangle formation.

Natural products against Alzheimer's disease: Pharmaco-therapeutics and biotechnological interventions

Nature has gifted mankind with a plethora of flora-bearing fruits, vegetables and nuts. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease and other neuronal dysfunctions. Accumulated evidence suggests that naturally occurring phyto-compounds, such as polyphenolic antioxidants found in fruits, vegetables, herbs and nuts, may potentially hinder neurodegeneration, and improve memory and cognitive function. Nuts such as walnut have also demonstrated neuroprotective effect against AD. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signalling pathways associated with protein folding and neuroinflammation. The neuroprotective effects of various naturally occurring compounds in AD is evaluating in this review.

Neuroprotective Effect of Natural Products Against Alzheimer’s Disease

Brain health benefits of Moringa oleifera

Several misspellings have been identified in our manuscript by Essa et al. 2012 (Neurochem Res DOI 10.1007/s11064012-0799-9) entitled ‘‘Neuroprotective Effect of Natural Products Against Alzheimer’s Disease’’. The corrections noted are: Under the heading of Edible brain food and Blue berry, the botanical name should be Vaccinium myrtillus L not Vaccinum angustifolium Under the heading of Strawberry, please read Ericaceae instead of Ericeae Please read the heading Papaya instead of Pappaya Under the heading of Green tea, Camellia sinesis should be replaced by Camellia sinensis Under the heading of Saffron, please read Iridaceae instead of Iridacea Under the heading of Pepper, please read Piper nigrum instead of Piper nigram and Piperaceae instead of Piperacea. Under the heading of Herbs and Alzheimer’s disease, please read Ginkgo biloba instead of Ginko biloba. Under the heading of Poncirus trifoliate, the heading and the corresponding text should read as Poncirus trifoliata instead of Poncirus trifoliate Under the heading of Paeonia suffruticosa, please read Paeonia suffruticosa instead of Paenoia suffruticosa

/pdf/erratum-to-neuroprotective-effect-of-natural-products-3s64csa0o2.pdf

Erratum to: Neuroprotective Effect of Natural Products Against Alzheimer’s Disease

Antiamyloidogenic effect of dates grown in Oman with reference to their possible protection against Alzheimer's disease

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Papers

Neuroprotective Effect of Natural Products Against Alzheimer’s Disease

Brain health benefits of Moringa oleifera

Erratum to: Neuroprotective Effect of Natural Products Against Alzheimer’s Disease

Antiamyloidogenic effect of dates grown in Oman with reference to their possible protection against Alzheimer's disease