Luz E. Vela
University of Houston
4 Papers
2 Citations
Luz E. Vela is an academic researcher from University of Houston. The author has contributed to research in topics: Intron & Cell. The author has an hindex of 2, co-authored 4 publications.
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Papers
Correction to Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2 [Molecular Cell 61, 520-534, (2016)]
Roxana S. Redis,Luz E. Vela,Weiqin Lu,Juliana Ferreira de Oliveira,Cristina Ivan,Cristian Rodriguez-Aguayo,Douglas Adamoski,Barbara Pasculli,Ayumu Taguchi,Yunyun Chen,Agustín F. Fernández,Luis Valledor,Katrien Van Roosbroeck,Samuel Chang,Maitri Y. Shah,Garrett Kinnebrew,Leng Han,Yaser Atlasi,Lawrence H. Cheung,Gilbert Yuanjay Huang,Paloma Monroig,Marc S. Ramirez,Tina Catela Ivkovic,Long Van,Hui Ling,Roberta Gafà,Sanja Kapitanović,Giovanni Lanza,James A. Bankson,Peng Huang,Stephen Y. Lai,Robert C. Bast,Michael G. Rosenblum,Milan Radovich,Mircea Ivan,Geoffrey Bartholomeusz,Han Liang,Mario F. Fraga,William R. Widger,Samir M. Hanash,Ioana Berindan-Neagoe,Gabriel Lopez-Berestein,Andre Luis Berteli Ambrosio,Sandra Martha Gomes Dias,George A. Calin +44 more
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Abstract 2871: Allele-specific modulation of cancer metabolism by a long noncoding RNA
Roxana S. Redis,Cristina Ivan,Luz E. Vela,Weiqin Lu,Cristian Rodriguez-Aguayo,Andre Lb. Ambrosio,Sandra Martha Gomes Dias,Ioana Berindan-Neagoe,George A. Calin +8 more
TL;DR: This study shows that the long non-codingRNA CCAT2, located at 8q24 amplicon on cancer risk associated rs6983267 SNP, regulates cancer metabolism in vitro and in vivo, in an allele-specific manner by binding the cleavage factor I (CFIm) complex with distinct affinities, complementary to the risk for colon cancer.
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Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2
Roxana S. Redis,Luz E. Vela,Weiqin Lu,Juliana Ferreira de Oliveira,Cristina Ivan,Cristian Rodriguez-Aguayo,Douglas Adamoski,Barbara Pasculli,Ayumu Taguchi,Yunyun Chen,Agustín F. Fernández,Luis Valledor,Katrien Van Roosbroeck,Samuel Chang,Maitri Y. Shah,Garrett Kinnebrew,Leng Han,Yaser Atlasi,Lawrence H. Cheung,Gilbert Yuanjay Huang,Paloma Monroig,Marc S. Ramirez,Tina Catela Ivković,Long Van,Hui Ling,Roberta Gafà,Sanja Kapitanović,Giovanni Lanza,James A. Bankson,Peng Huang,Stephan Y. Lai,Robert C. Bast,Michael G. Rosenblum,Milan Radovich,Mircea Ivan,Geoffrey Bartholomeusz,Han Liang,Mario F. Fraga,William R. Widger,Samir M. Hanash,Ioana Berindan-Neagoe,Ioana Berindan-Neagoe,Ioana Berindan-Neagoe,Gabriel Lopez-Berestein,Andre Luis Berteli Ambrosio,Sandra Martha Gomes Dias,George A. Calin +46 more
TL;DR: The CCAT2 interaction with the CFIm complex fine-tunes the alternative splicing of Glutaminase (GLS) by selecting the poly(A) site in intron 14 of the precursor mRNA.