Luyi Jiang

TL;DR: These findings highlight an essential role of MCSs in intracellular cholesterol transport, and further work is needed to unveil how various routes are regulated and integrated to maintain proper cholesterol distribution and homeostasis in eukaryotic cells.

TL;DR: In this article , the authors analyzed the cholesterol atlas in the tumor microenvironment and found that intratumoral T cells have cholesterol deficiency, while immunosuppressive myeloid cells and tumor cells display cholesterol abundance.

TL;DR: This study reveals a new cholesterol transport pathway along the lysosome-peroxisome-ER membrane contacts in the cell, and shows that cholesterol is delivered from 3H-labeled peroxisomes or PI(4,5)P2-containing liposomes to the ER in vitro, and that the presence of perox isomes augments cholesterol transfer from lysOSomes toThe ER.

TL;DR: It is shown that the previously unannotated protein TMEM241 is required for cholesterol egressing from lysosomes through amphotericin B-based genome-wide CRISPR-Cas9 KO screening and is a Golgi-localized UDP-GlcNAc transporter and loss ofTMEM241 causes cholesterol accumulation in lysoomes because of the impaired M6P-dependent lysOSomal targeting of NPC2.