We consider the impact of surface hydrodynamics on the interplay between membrane curvature and lipid composition in coarsening processes on model systems for biomembranes. This includes the influence on scaling laws and equilibrium configurations, which are investigated by computational studies of a surface two-phase flow problem with additional phase-dependent bending terms. These additional terms geometrically favor specific configurations. We find that the effect of hydrodynamics strongly depends on the composition. In situations where the composition allows a realization of a geometrically favored configuration, hydrodynamics enhances the evolution toward this configuration. We restrict our model and numerics to stationary surfaces of varying curvature and validate the numerical approach with various benchmark problems and convergence studies.

https://pubs.aip.org/aip/pof/article-pdf/doi/10.1063/5.0145884/16813080/042102_1_5.0145884.pdf

The interplay of geometry and coarsening in multicomponent lipid vesicles under the influence of hydrodynamics

We consider sharp interface asymptotics for a phase field model motivated by lipid raft formation on near spherical biomembranes involving a coupling between the local mean curvature and the local composition. A reduced diffuse interface energy depending only on the membrane composition is introduced and a $\\Gamma$-limit is derived. It is shown that the Euler–Lagrange equations for the limiting functional and the sharp interface energy coincide. Finally, we consider a system of gradient flow equations with conserved Allen–Cahn dynamics for the phase field model. Performing a formal asymptotic analysis, we obtain a system of gradient flow equations for the sharp interface energy coupling geodesic curvature flow for the phase interface to a fourth order PDE free boundary problem for the surface deformation. 

On the sharp interface limit of a phase field model for near spherical two phase biomembranes

pdf/generation-and-motion-of-interfaces-in-a-mass-conserving-4cykhw7tq2.pdf

Generation and Motion of Interfaces in a Mass-Conserving Reaction-Diffusion System

Reaction-diffusion models with nonlocal constraints naturally arise as limiting cases of coupled bulk-surface models of intracellular signalling. In this paper, a minimal, mass-conserving model of cell-polarization on a curved membrane is analyzed in the limit of slow surface diffusion. Using the tools of formal asymptotics and calculus of variations, we study the characteristic wave-pinning behavior of this system on three dynamical timescales. On the short timescale, generation of an interface separating high- and low-concentration domains is established under suitable conditions. Intermediate timescale dynamics is shown to lead to a uniform growth or shrinking of these domains to sizes which are ﬁxed by global parameters. Finally, the long time dynamics reduces to area-preserving geodesic curvature ﬂow that may lead to multi-interface steady state solutions. These results provide a founda-tion for studying cell polarization and related phenomena in biologically relevant geometries.

Generation and motion of interfaces in a mass-conserving reaction-diffusion system

We formulate a well-posedness and approximation theory for a class of generalised saddle point problems with a specific form of constraints. In this way we develop an approach to a class of fourth order elliptic partial differential equations with point constraints using the idea of splitting into coupled second order equations. An approach is formulated using a penalty method to impose the constraints. Our main motivation is to treat certain fourth order equations involving the biharmonic operator and point Dirichlet constraints for example arising in the modelling of biomembranes on curved and flat surfaces but the approach may be applied more generally. The theory for well-posedness and approximation is presented in an abstract setting. Several examples are described together with some numerical experiments.

Second order splitting of a class of fourth order PDEs with point constraints

We derive and analyse an energy to model lipid raft formation on biological membranes involving a coupling between the local mean curvature and the local composition. We apply a perturbation method recently introduced by Fritz, Hobbs and the first author to describe the geometry of the surface as a graph over an undeformed Helfrich energy minimising surface. The result is a surface Cahn-Hilliard functional coupled with a small deformation energy We show that suitable minimisers of this energy exist and consider a gradient flow with conserved Allen-Cahn dynamics, for which existence and uniqueness results are proven. Finally, numerical simulations show that for the long time behaviour raft-like structures can emerge and stablise, and their parameter dependence is further explored.

/pdf/domain-formation-via-phase-separation-for-spherical-4j2c2sybta.pdf

Domain formation via phase separation for spherical biomembranes with small deformations

In this contribution to the proceedings of the 11th Mathematical Society of Japan (MSJ) Seasonal Institute (July 2018) we give an overview of some recent work on a mathematical model for small deformations of a spherical membrane. The idea is to consider perturbations to minimisers of a surface geometric energy. The model is obtained from consideration of second order approximations to a perturbed energy. In particular, the considered problems involve particle constraints and surface phase field energies.

Small deformations of spherical biomembranes

Domain formation via phase separation for spherical biomembranes with small deformations.

We consider sharp interface asymptotics for a phase field model of two phase near spherical biomembranes involving a coupling between the local mean curvature and the local composition proposed by the first and second authors. The model is motivated by lipid raft formation. We introduce a reduced diffuse interface energy depending only on the membrane composition and derive the $\Gamma-$limit. We demonstrate that the Euler-Lagrange equations for the limiting functional and the sharp interface energy coincide. Finally, we consider a system of gradient flow equations with conserved Allen-Cahn dynamics for the phase field model. Performing a formal asymptotic analysis we obtain a system of gradient flow equations for the sharp interface energy coupling geodesic curvature flow for the phase interface to a fourth order PDE free boundary problem for the surface deformation.

On the sharp interface limit of a phase field model for near-spherical two phase biomembranes

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Domain formation via phase separation for spherical biomembranes with small deformations

Small deformations of spherical biomembranes

Domain formation via phase separation for spherical biomembranes with small deformations.

On the sharp interface limit of a phase field model for near-spherical two phase biomembranes