Łukasz Balewski
Gdańsk Medical University
22 Papers
8 Citations
Łukasz Balewski is an academic researcher from Gdańsk Medical University. The author has contributed to research in topics: Chemistry & Copper. The author has an hindex of 6, co-authored 13 publications.
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Papers
Biological activities of guanidine compounds.
TL;DR: Recent achievements in the synthesis of guanidine-containing molecules with diverse chemical, biochemical and pharmacological properties make them of great importance to the design and development of novel drugs acting at CNS, anti-inflammatory agents, inhibitors of Na+/H+ exchanger, inhibitor of NO synthase, antithrombotic, antidiabetic and chemotherapeutic agents as well as guanidinium-based transporters and vectors.
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A Mini-Review: Recent Advances in Coumarin-Metal Complexes With Biological Properties
TL;DR: The coumarin nucleus is a recurring motif in both natural and synthetic compounds that exhibit a broad spectrum of biological properties including anticoagulant, anti-inflammatory, antioxidant, antiviral, antimicrobial and anticancer agents as well as enzyme inhibitors as mentioned in this paper.
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Imidazoline scaffold in medicinal chemistry: a patent review (2012–2015)
TL;DR: It is shown that 2-Substituted imidazolines and theirImidazolidine tautomers cannot be regarded as isofunctional structures and the term ‘imidazoline scaffold’ should be treated with caution.
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Structural diversity of copper(II) complexes with N-(2-pyridyl)imidazolidin-2-ones(thiones) and their in vitro antitumor activity.
Łukasz Balewski,Franciszek Sączewski,Patrick J. Bednarski,Maria Gdaniec,Ewa Borys,Anna Makowska +5 more
TL;DR: The only complexes that showed remarkably increased activity in comparison to the free ligands were those obtained from N-(2-pyridyl)imidazolidine-2-thiones 4c and 4e substituted with alkyl group at position 4 or 5 of pyridine ring.
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The Elusive Paal-Knorr Intermediates in the Trofimov Synthesis of Pyrroles: Experimental and Theoretical Studies.
Jarosław Sączewski,Joanna Fedorowicz,Maria Gdaniec,Paulina Wiśniewska,Emilia Sieniawska,Zuzanna Drażba,Justyna Rzewnicka,Łukasz Balewski +7 more
TL;DR: Quantum chemical calculations of a [3,3]sigmatropic rearrangement of the N,O-divinyl hydroxylamines to corresponding imino-aldehydes (Paal-Knorr intermediates) revealed that this reaction proceeds via chairlike transition state and is exothermic.
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