Lukas John
University Hospital Heidelberg
25 Papers
1 Citations
Lukas John is an academic researcher from University Hospital Heidelberg. The author has contributed to research in topics: Medicine & Multiple myeloma. The author has an hindex of 1, co-authored 1 publications.
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Papers
Characterizing the role of the immune microenvironment in multiple myeloma progression at a single-cell level
Carolina Schinke,Alexandra M Poos,Michael A Bauer,Lukas John,Sarah K. Johnson,Shayu Deshpande,L. Carrillo,Daisy Alapat,Leo Rasche,Sharmilan Thanendrarajan,Maurizio Zangari,Samer Al Hadidi,Frits van Rhee,Faith E. Davies,Marc S. Raab,Gareth J. Morgan,Niels Weinhold +16 more
TL;DR: Changes in immune cell populations as disease progressed that were characterized by a substantial decrease in memory and naïve CD4 T cells and an increase in CD8+ effector T Cells and T-regulatory cells can help to develop immune based strategies for patient stratification and early therapeutic intervention.
Resolving therapy resistance mechanisms in multiple myeloma by multi-omics subclone analysis.
Alexandra M Poos,Nina Prokoph,Moritz Jakob Przybilla,Jan-Philipp Mallm,Simon Steiger,Lukas John,Stephan M Tirier,Katharina Bauer,Anja Baumann,Umair Munawar,Leo Rasche,K. Martin Kortüm,Nicola Giesen,Philipp Reichert,Stefanie Huhn,Carsten Müller-Tidow,Hartmut Goldschmidt,Oliver Stegle,Marc S. Raab,Karsten Rippe,Niels Weinhold +20 more
TL;DR: In this paper , the authors integrated whole genome sequencing, single-cell transcriptomics (scRNA-seq), and chromatin accessibility (scATAC-seq) together with mitochondrial DNA (mtDNA) mutations to define subclonal architecture and evolution for longitudinal samples from 15 relapsed/refractory multiple myeloma (RRMM) patients.
Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level
Lukas John,Alexandra M Poos,Alexander Brobeil,Carolina Schinke,Stefanie Huhn,Nina Prokoph,Raphael Lutz,B. Wagner,Maurizio Zangari,Stephan M Tirier,Jan-Philipp Mallm,Sabrina Schumacher,Dominik Vonficht,Llorenç Solé-Boldo,S. Quick,Simon Steiger,Moritz Jakob Przybilla,Katharina Bauer,Anja Baumann,S. Hemmer,Christoph Rehnitz,Christian Lückerath,Christos Sachpekidis,Gunhild Mechtersheimer,Uwe Haberkorn,Antonia Dimitrakopoulou-Strauss,Philipp Reichert,Bart Barlogie,Carsten Müller-Tidow,Hartmut Goldschmidt,Jens Hillengass,Leo Rasche,S. Haas,Frits van Rhee,Karsten Rippe,Marc S. Raab,Sandra Sauer,Niels Weinhold +37 more
TL;DR: Multi-region sequencing on paired random bone marrow and focal lesion samples from 17 newly diagnosed patients demonstrates the relevance of considering spatial heterogeneity in multiple myeloma with potential implications for models of cell-cell interactions and disease progression.
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Application of an artificial intelligence-based tool in [18F]FDG PET/CT for the assessment of bone marrow involvement in multiple myeloma.
Christos Sachpekidis,Olof Enqvist,Johannes Ulén,Annette Kopp-Schneider,Leyun Pan,Anna Jauch,Marina Hajiyianni,Lukas John,Niels Weinhold,Sandra Sauer,Hartmut Goldschmidt,Lars Edenbrandt,Antonia Dimitrakopoulou-Strauss +12 more
TL;DR: The proposed automated method for BM metabolism assessment is based on an initial CT-based segmentation of the skeleton, its transfer to the SUV PET images, the subsequent application of different SUV thresholds, and refinement of the resulting regions using postprocessing.
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Comprehensive Comparison of Early Relapse and End-Stage Relapsed Refractory Multiple Myeloma
Alexandra M Poos,Alexandra M Poos,Nicola Giesen,Nicola Giesen,Calogerina Catalano,Calogerina Catalano,Nagarajan Paramasivam,Daniel Huebschmann,Lukas John,Anja Baumann,Jason Hochhaus,Carsten Mueller-Tidow,Sandra Sauer,Stefanie Huhn,Matthias Schlesner,Benedikt Brors,Hartmut Goldschmidt,Marc S. Raab,Marc S. Raab,Niels Weinhold,Niels Weinhold +20 more
TL;DR: Analysis of mutational signatures revealed a major impact of signature MM1 (associated with melphalan-exposure), in 66% of RRMM patients, and upregulated genes in ERMM and RRMM were enriched for epithelial-mesenchymal transition, hypoxia, glycolysis and KRAS/IL6-JAK-STAT3 signaling.
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