Luisa P. Cacheaux
Helen Wills Neuroscience Institute
11 Papers
175 Citations
Luisa P. Cacheaux is an academic researcher from Helen Wills Neuroscience Institute. The author has contributed to research in topics: Epileptogenesis & Messenger RNA. The author has an hindex of 10, co-authored 11 publications. Previous affiliations of Luisa P. Cacheaux include University of California, Berkeley & University of Texas at Austin.
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Papers
Transcriptome Profiling Reveals TGF-β Signaling Involvement in Epileptogenesis
Luisa P. Cacheaux,Sebastian Ivens,Yaron David,Alexander J Lakhter,Guy Bar-Klein,Michael Y. Shapira,Uwe Heinemann,Alon Friedman,Daniela Kaufer +8 more
TL;DR: The present data identifies the TGF-β pathway as a novel putative epileptogenic signaling cascade and therapeutic target for the prevention of injury-induced epilepsy.
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Astrocytic Dysfunction in Epileptogenesis: Consequence of Altered Potassium and Glutamate Homeostasis?
Yaron David,Luisa P. Cacheaux,Sebastian Ivens,Ezequiel Lapilover,Uwe Heinemann,Daniela Kaufer,Alon Friedman +6 more
TL;DR: The data indicate a transcription-mediated astrocytic transformation early during epileptogenesis, which suggests that the resulting reduction in the clearance of extracellular potassium underlies frequency-dependent neuronal hyperexcitability and network synchronization.
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Changes in Brain MicroRNAs Contribute to Cholinergic Stress Reactions
Ari Meerson,Luisa P. Cacheaux,Ki Ann Goosens,Robert M. Sapolsky,Hermona Soreq,Daniela Kaufer +5 more
TL;DR: In this article, the authors report that stress changes brain microRNA (miR) expression and that some of these stress-regulated miRs regulate alternative splicing in the brain, via incompletely understood mechanisms.
Changes in Brain MicroRNAs Contribute to Cholinergic Stress Reactions
Ari Meerson,Luisa P. Cacheaux,Ki Ann Goosens,Robert M. Sapolsky,Hermona Soreq,Daniela Kaufer +5 more
- 01 Aug 2009
TL;DR: Stress-induced changes in brain microRNA (miR) expression are shown and it is suggested that, by regulating splicing factors and their targets, these changes modify both alternative splicing and cholinergic neurotransmission in the stressed brain.
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Impairment of hyperpolarization-activated, cyclic nucleotide- gated channel function by the intravenous general anesthetic propofol
Luisa P. Cacheaux,Norbert Topf,Gareth R. Tibbs,Ulrich Schaefer,Roberto Levi,Neil L. Harrison,Geoffrey W. Abbott,Peter A. Goldstein +7 more
TL;DR: The data suggest that propofol modulation of HCN channel gating is an important molecular mechanism that can contribute to the depression of central nervous system function and also lead to bradyarrhythmias in patients receiving prop ofol during surgical anesthesia.
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