Luisa Gatta
Seconda Università degli Studi di Napoli
20 Papers
86 Citations
Luisa Gatta is an academic researcher from Seconda Università degli Studi di Napoli. The author has contributed to research in topics: TRPV1 & Neuropathic pain. The author has an hindex of 15, co-authored 20 publications.
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Papers
1-(2',4'-dichlorophenyl)-6-methyl-N-cyclohexylamine-1,4-dihydroindeno[1,2-c] pyrazole-3-carboxamide, a novel CB2 agonist, alleviates neuropathic pain through functional microglial changes in mice
Livio Luongo,Enza Palazzo,S Tambaro,Catia Giordano,Luisa Gatta,Mariantonietta Scafuro,F. sca Rossi,P Lazzari,L Pani,V. de Novellis,Marzia Malcangio,Sabatino Maione +11 more
TL;DR: Investigation of chronic treatment with a selective agonist of cannabinoid type 2 receptor (CB2), 1-(2',4'-dichlorophenyl)-6-methyl-N-cyclohexylamine-1,4-dihydroindeno[1,2-c]pyrazole-3 carboxamide (NESS400) finds that repeated treatment with NESS400 significantly alleviated neuropathic mechanical allodynia and thermal hyperalgesia.
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TRPV1-Dependent and -Independent Alterations in the Limbic Cortex of Neuropathic Mice: Impact on Glial Caspases and Pain Perception
Catia Giordano,Luigia Cristino,Livio Luongo,Dario Siniscalco,Stefania Petrosino,Fabiana Piscitelli,Ida Marabese,Luisa Gatta,Francesca Rossi,Roberta Imperatore,Enza Palazzo,Vito de Novellis,Vincenzo Di Marzo,Sabatino Maione +13 more
TL;DR: It is suggested that SNI triggers both TRPV1-dependent and independent glutamate- and caspase-mediated cross-talk among IL-PL cortex neurons and glia, which either participates or counteracts pain.
Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy.
Rita Citraro,Emilio Russo,Francesca Scicchitano,Clementina M. van Rijn,Donato Cosco,Carmen Avagliano,Roberto Russo,Giuseppe D'Agostino,Stefania Petrosino,Francesca Guida,Luisa Gatta,Gilles van Luijtelaar,Sabatino Maione,Vincenzo Di Marzo,Antonio Calignano,Giovambattista De Sarro +15 more
TL;DR: The data demonstrate that PEA has anti-absence properties in the WAG/Rij rat model and that such properties depend on PPAR-α and indirect activation of CB1 receptors.
99
The A1 adenosine receptor as a new player in microglia physiology
Livio Luongo,Francesca Guida,Roberta Imperatore,Francesco Napolitano,Luisa Gatta,Luigia Cristino,Catia Giordano,Dario Siniscalco,V. Di Marzo,Giulia Bellini,Riccardo Petrelli,Loredana Cappellacci,A. Usiello,V. de Novellis,Francesca Rossi,Sabatino Maione +15 more
TL;DR: It is found that microglial cells express A1AR and that it is highly upregulated upon ATP treatment, and it is observed that selective stimulation of A1 AR inhibits the morphological activation of microglia, possibly by suppressing the Ca2+ influx induced by ATP treatment.
96
The blockade of the transient receptor potential vanilloid type 1 and fatty acid amide hydrolase decreases symptoms and central sequelae in the medial prefrontal cortex of neuropathic rats
Vito de Novellis,Daniela Vita,Luisa Gatta,Livio Luongo,Giulia Bellini,Maria De Chiaro,Ida Marabese,Dario Siniscalco,Serena Boccella,Fabiana Piscitelli,Vincenzo Di Marzo,Enza Palazzo,Francesco Rossi,Sabatino Maione +13 more
TL;DR: Data suggest a possible involvement of endovanilloids in the cortical plastic changes associated with peripheral nerve injury and indicate that therapies able to normalizeendovanilloid transmission may prove useful in ameliorating the symptoms and central sequelae associated with neuropathic pain.