Introduction Conjugated estrogens/bazedoxifene (CE/BZA) relieves menopausal symptoms and increases bone mineral density (BMD).Objective To evaluate CE/BZA in a Latin American subpopulation from randomized, double-blind, phase-3, multinational trials.Methods Safety data were pooled from three trials from non-hysterectomized postmenopausal Latin American women assigned to CE 0.45 mg/BZA 20 mg (n = 227), CE 0.625 mg/BZA 20 mg (n = 222), or placebo (n = 193). Efficacy outcomes from one study included changes in hot flush frequency at week 12 in women with at least seven moderate/severe hot flushes/day or 50/week at baseline (n = 39), and from baseline to month 12 for BMD (n = 381) and genitourinary syndrome of menopause (GSM) (women with baseline GSM; n = 189).Results At week 12, women taking CE/BZA had four to five fewer moderate/severe hot flushes/day vs. placebo. At month 12, percentage changes in BMD with CE 0.45 mg/BZA 20 mg, CE 0.625 mg/BZA 20 mg, and placebo were 1.2%, 1.6%, and –1.1% for lumba...

Evaluation of efficacy and safety of conjugated estrogens/bazedoxifene in a Latin American population.

El manual fue en un principio escrito para el estudiante de medicina en los cursos introductorios a la Semiologia, pero su contenido y la actualizacion de esta edicion hacen que sea, ademas, muy util para el medico general y el especialista que necesitan conocer la referencia normal tanto del examen fisico como de los metodos de exploracion. Contenido: Descripcion general, signos vitales, piel y anexos. Presion arterial. Organos de los sentidos y cuello. Sistema cardiovascular. Sistema vascular. Sistema respiratorio Examen de las glandulas mamarias. Examen del abdomen. Examen ginecologico. Sistema nervioso. Sistema osteoartromuscular. Examen del nino normal.

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Publicaciones de egresados, docentes e investigadores de la Universidad de Antioquia

Publicaciones De Egresados, Docentes E Investigadores De La Universidad De Antioquia

Uterine bleeding is a common reason why women discontinue menopausal hormone therapy (HT). This systematic review compared bleeding profiles reported in studies for continuous-combined HT approved in North America and Europe for moderate to severe vasomotor symptoms in postmenopausal women with a uterus. Non-head-to-head studies showed that uterine bleeding varies by formulation and administration route, with oral having a better bleeding profile than transdermal formulations. Cumulative amenorrhea over a year ranged from 18 to 61% with oral HT and from 9 to 27% with transdermal HT, as reported for continuous-combined HT containing 17β-estradiol (E2)/progesterone (P4) (56%), E2/norethisterone acetate (NETA) (49%), E2/drospirenone (45%), conjugated equine estrogens/medroxyprogesterone acetate (18-54%), ethinyl estradiol/NETA (31-61%), E2/levonorgestrel patch (16%), and E2/NETA patch (9-27%). Amenorrhea rates and the mean number of bleeding/spotting days improved over time. The oral E2/P4 combination was amongst those with lower bleeding rates and may be an appropriate alternative for millions of women seeking bioidentical HT and/or those who have bleeding concerns with other HT.

Uterine bleeding with hormone therapies in menopausal women: a systematic review.

The impact of a monophasic continuous estro-progestogenic treatment on Latin American menopausal women.

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The impact of a monophasic continuous estro-progestogenic treatment on Latin American menopausal women.