Lucy Rodemich
Drexel University
6 Papers
98 Citations
Lucy Rodemich is an academic researcher from Drexel University. The author has contributed to research in topics: Glycosylation & Glycan. The author has an hindex of 6, co-authored 6 publications. Previous affiliations of Lucy Rodemich include Saint Louis University & Eastern Virginia Medical School.
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Papers
Identification and development of fucosylated glycoproteins as biomarkers of primary hepatocellular carcinoma.
Mary Ann Comunale,Mengjun Wang,Julie Hafner,Jonathan Krakover,Lucy Rodemich,Brent Kopenhaver,Ronald E. Long,Omer Junaidi,Adrian M. Di Bisceglie,Timothy M. Block,Anand Mehta +10 more
TL;DR: Using a high-throughput plate based approach, N-linked glycan analysis from serum samples depleted of the major acute phase proteins, followed by targeted lectin extraction of those proteins containing changes in glycosylation were performed.
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Increased Levels of Galactose-Deficient Anti-Gal Immunoglobulin G in the Sera of Hepatitis C Virus-Infected Individuals with Fibrosis and Cirrhosis
Anand Mehta,Ronald E. Long,Mary Ann Comunale,Mengjun Wang,Lucy Rodemich,Jonathan Krakover,Ramila Philip,Jorge A. Marrero,Raymond A. Dwek,Timothy M. Block +9 more
TL;DR: Using comparative glycoproteomics, a glycoprotein is identified that is altered both in amount and in glycosylation as a function of liver fibrosis and cirrhosis, an immunoglobulin G (IgG) molecule reactive to the heterophilic alpha-Gal epitope.
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N‐linked glycosylation of the liver cancer biomarker GP73
Pamela A. Norton,Mary Ann Comunale,Jonathan Krakover,Lucy Rodemich,Natalie Pirog,Anthony D'Amelio,Ramila Philip,Anand Mehta,Timothy M. Block +8 more
TL;DR: A method to interrogate the glycans added to either the near full length protein or at a particular sequon is developed, providing proof of concept that a small peptide embedded in a heterologous context can preserve both fucosylation and a high level of branching of oligosaccharides added.
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Glycomic Characterization of Prostate Specific Antigen and Prostatic Acid Phosphatase in Prostate Cancer and Benign Disease Seminal Plasma Fluids
Krista Y. White,Lucy Rodemich,Julius O. Nyalwidhe,Mary Ann Comunale,Mary Ann Clements,Raymond S. Lance,Paul F. Schellhammer,Anand Mehta,O. John Semmes,Richard R. Drake +9 more
TL;DR: The glycans identified in these studies will allow for more defined targeting of prostate disease-specific changes for PAP, PSA and other secreted prostatic glycoproteins.
The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection.
Elizabeth P. Blankenhorn,Lucy Rodemich,Cristina Martin-Fernandez,Jean Leif,Dale L. Greiner,John P. Mordes +5 more
TL;DR: The data suggest that the expression of autoimmune diabetes is a complex process that requires both major histocompatibility complex genes that confer susceptibility and additional genes such as Iddm4 and I ddm20 that operate only in the context of specific environmental perturbants, amplifying the immune response and the rate of disease progression.
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