Lucy Lam
University of South Florida
5 Papers
Lucy Lam is an academic researcher from University of South Florida. The author has contributed to research in topics: Medicine & Microglia. The author has an hindex of 3, co-authored 3 publications.
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Papers
Antiretroviral medications disrupt microglial phagocytosis of β-amyloid and increase its production by neurons: Implications for HIV-associated neurocognitive disorders
Brian Giunta,Jared Ehrhart,Demian Obregon,Lucy Lam,Lisa Le,Jingji Jin,Francisco Fernandez,Jun Tan,R. Douglas Shytle +8 more
TL;DR: It is reported for the first time that these antiretroviral compounds generally increase Aβ generation in SweAPP N2a cells and markedly inhibit microglial phagocytosis of FITC-Aβ1-42 peptides in murine microglia, suggesting these compounds may consequently contribute to cognitive decline observed in HIV associated neurocognitive disorders (HAND).
Safety and efficacy of zilucoplan in patients with generalised myasthenia gravis (RAISE): a randomised, double-blind, placebo-controlled, phase 3 study
James F. Howard,Saskia Bresch,Angela Genge,Channa Hewamadduma,John L. Hinton,Yessar Hussain,Raul Juntas-Morales,Henry J. Kaminski,Angelina H. Maniaol,Renato Mantegazza,Masayuki Masuda,Kumaraswamy Sivakumar,Marek Śmiłowski,Kimiaki Utsugisawa,Tuan Vu,Michael D. Weiss,Małgorzata Zajda,Babak Boroojerdi,Melissa Brock,Petra Duda,Mark Vanderkelen,Maria Isabel Leite,Jeanne Teitelbaum,Michael W. Nicolle,Emilien Bernard,Juliette Svahn,Marco Spinazzi,Tanya Stojkovic,Sophie Demeret,N. Weiss,Loïc Le Guennec,Christine Tranchant,Aleksandra Nadaj-Pakleza,Jean-Baptiste Chanson,M. Suliman,Céline Tard,Jana Zschüntzsch,Jens Schmidt,Stefanie Glaubitz,Rachel Zeng,M D Scholl,Markus C. Kowarik,U. Ziemann,Markus Krumbholz,Pascal Martin,Christoph Ruschil,Jutta Dünschede,Benjamin Berger,Andreas Totzeck,Tim Hagenacker,Benjamin Stolte,Raffaele Iorio,Amelia Evoli,Silvia Falso,Carlo Antozzi,Rita Frangiamore,Fiammetta Vanoli,Elena Rinaldi,Kazushi Deguchi,Naoya Minami,Yuriko Nagane,Yasushi Suzuki,Sayaka Ishida,Shigeaki Suzuki,Jin Nakahara,Shunsuke Yoshimura,Shingo Konno,Akiyuki Uzawa,Tomoya Kubota,Masanori Takahashi,Tatsusada Okuno,Hiroyuki Murai,Nils Erik Gilhus,Marion I. Boldingh,T. H. Rønning,U. Chyrchel-Paszkiewicz,Klaudiusz Kumor,Tomasz Zielinski,Krzysztof Banaszkiewicz,Michal Blaż,Agata Klosek,Mariola Świderek-Matysiak,Andrzej Szczudlik,A. Pasko,Lech Szczechowski,Marta Banach,Jan Ilkowski,Solangel Garcia,Ana Segura,J. T. Sans,N. Fernández,Elena Cortes Vicente,P. R. Armenteros,Mohammad R. Ashraghi,Ana Cavey,A P. Emery,K.L. Liow,Sharon Yegiaian,Alexandru Barboi,R.M. Vazquez,Joshua Lennon,Robert M. Pascuzzi,Cynthia Bodkin,Sandy Guingrich,Adam Comer,C. Bromberg,Teresa Janecki,S Saba,M. Tellez,Bakri Elsheikh,Miriam Freimer,Sarah Heintzman,Raghav Govindarajan,Jeffrey T. Guptill,Janice M. Massey,Vern C. Juel,Natalia Sanchez Gonzalez,Ali A. Habib,Tahseen Mozaffar,Manisha Kak Korb,Namita Goyal,Hannah C. Machemehl,Georgios Manousakis,Jeffrey Allen,Emily Harper,Constantine Farmakidis,Mazen M. Dimachkie,Mamatha Pasnoor,Salma Akhter,Said R. Beydoun,Courtney E. McIlduff,Joan Nye,Bhaskar Roy,B. Sheldon,Richard Nowak,Ben Barnes,Michael H. Rivner,Niraja Suresh,Jessica D. Shaw,Brittany Harvey,Lucy Lam,Nikki Lynn Thomas,Manisha Chopra,Rebecca Traub,Sarah M. Jones,M. A. Wagoner,Radwa Aly,Jonathan L. Katz,Henry H. Chen,Robert G. Miller,Liberty Jenkins,Shaida Khan,Bhupen Khatri,Lisa M. Sershon,Pantelis Pavlakis,Shara Holzberg,Yuebing Li,Irys B Caristo,Roberto Marquardt,Debbie Hastings,Jacob Rube,Robert P. Lisak,Aparna Choudhury,Katherine Ruzhansky,Amit Sachdev,Susan M. Shin,Joan Bratton,Mary Fetter,Naya McKinnon,Jonathan McKinnon,Laura Sissons-Ross,Barbara J. Distad +171 more
TL;DR: Zilucoplan treatment showed rapid and clinically meaningful improvements in myasthenia gravis-specific efficacy outcomes, had a favourable safety profile, and was well tolerated, with no major safety findings.
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•Journal Article
HIV-1 Tat-induced microglial activation and neuronal damage is inhibited via CD45 modulation: A potential new treatment target for HAND
TL;DR: Results suggest therapeutic agents that activate CD45 PTP signaling may be effective in suppressing microglial activation associated with HAND.
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Safety and efficacy of rozanolixizumab in patients with generalised myasthenia gravis (MycarinG): a randomised, double-blind, placebo-controlled, adaptive phase 3 study
Vera Bril,Artur Druzdz,Julian Grosskreutz,Ali Habib,Renato Mantegazza,Sabrina Sacconi,Kimiaki Utsugisawa,John Vissing,Tuan Vu,Mary Boehnlein,Ali Bozorg,M. Gayfieva,Bernhard Greve,F. Woltering,Henry J. Kaminski,Angela Genge,Rami Massie,Maxime Bérubé,Lubna Daniyal,Shabber Mannan,Eduardo Ng,Ritesh Raman,Evelyn Sarpong,Monica Alcantara,Annie Dionne,Zaeem A. Siddiqi,Derrick Blackmore,Faraz S. Hussain,Genevieve Matte,Stephan A Botez,Michaela Tyblova,M. Jakubíkova,Jana Junkerova,Nanna Witting,Sonja Holm-Yildiz,Mads Godtfeldt Stemmerik,Henning Andersen,Izabella Obál,Guilhem Solé,Stéphane Mathis,Marie Helene Violleau,Christine Tranchant,Jean-Baptiste Chanson,Aleksandra Nadaj-Pakleza,Manuela Gambella,Michele Cavalli,Tanya Stojkovic,Sophie Demeret,Loïc Le Guennec,Giorgia Querin,N. Weiss,Marion Masingue,Laurent Magy,Karima Ghorab,I. Rukhadze,Alexander Tsiskaridze,M Janelidze,Temur Margania,Florian Then Bergh,A. Al Kalb,Bianca Meilick,Mandy Reuschel,A. Unterlauft,C. Goedel,Tim Hagenacker,Andreas Totzeck,Benjamin Stolte,Franz Blaes,Christine Bindler,Annekathrin Roediger,Christian Geis,Jens Schmidt,Jana Zschüntzsch,Stefanie Meyer,K. Kummer,Stefanie Glaubitz,Rachel Zeng,Heinz Wiendl,Luisa Klotz,Anna Lammerskitten,J. Lünemann,Péter Diószeghy,Lorenzo Maggi,Elena Rinaldi,Matteo Gastaldi,Federico Mazzacane,Pietro Businaro,Raffaele Iorio,Giovanni Antonini,Laura Fionda,Rita Rinaldi,Simone Rossi,Francesco Habetswallner,Francesco Tuccillo,Eiko Uenaka,Masanori Takahashi,Keiko Higashi,Makoto Kinoshita,Emi Yoneda,Noriko Nakamura,Tomoya Kubota,Masami Ono,Taku Hatano,Kazumasa Yokoyama,Yutaka Oji,Yuji Tomizawa,Akiyuki Uzawa,Manato Yasuda,Sachiko Akita,Yukiko Ozawa,Yosuke Onishi,Mikio Takaki,Hiromi Yamada,Kanako Minemoto,Nana Izawa,M. Nakayama,Masayuki Masuda,Nobuhiro Ido,Yoshihiko Okubo,Makiko Naito,Seiko Yoshida,Yuri Fukushige,Akira Tsujino,Atsushi Nagaoka,Teiichiro Miyazaki,Shunsuke Yoshimura,Takuro Hirayama,Tomoaki Shima,Naoko Okamoto,Rikizo Matsumoto,Kenji Sekiguchi,Takehiro Ueda,Norio Chihara,Emi Sunagawa,Ayaka Suzuki,Shigeaki Suzuki,Kei Ishizuchi,Yasushi Suzuki,Mitsuo Yata,Yuka Komatsu,Kenichi Tsukita,Genya Watanabe,Kazuki Saito,Emiko Kawasaki,Naoki Yamamoto,Hirohiko Ono,Tomoko Tsuda,Shigeki Ohashi,Yuka Fujisawa,Yumiko Yokota,Yuriko Nagane,Yuka Takematsu,Hiroyuki Naito,Konrad Rejdak,Sebastian Szklener,Tomasz Berkowicz,Paulina Budzińska,Marek Halas,Leonid Zaslavskiy,E. A. Skornyakova,Sergey Kotov,E. Novikova,Olga V. Churakova (Sidorova),V.V. Goldobin,Tatiana Alekseeva,P.S. Isabekova,Nadezhda Malkova,Denis Korobko,Gordana Djordjevic,Aleksandar Stojanov,Stojan Peric,Dragana Lavrnic,Ivo Bozovic,Aleksa Palibrk,Carlos Casasnovas,Velina Nedkova-Hristova,N. Fernández,Elena Cortes Vicente,Luis Antonio Querol Gutierrez,Maria Salvado Figueras,Raul Juntas Morales,Daniel Tejerina,Albert Saiz,Yolanda Morgado,Gerardo Gutiérrez Gutiérrez,Paqui Iniesta,J.E. Meca Lallana,Yuh-Cherng Guo,Hou Chang Chiu,Jiann-Horng Yeh,Ya Hui Chen,Mei Fen Lee,Yi-Chung Lee,Kuan Lin Lai,Said R. Beydoun,Salma Akhter,Lucy Lam,Alisha Thomas,Michael H. Rivner,Brandy Quarles,Dale L. Lange,Shara Holzberg,Pantelis Pavlakis,Radwa Aly,Lisa Ashworth,Kathryn E. Bender,K. Bond,Sara J. Byerly,James B. Caress,Catherine Franklin,M.P. Hiatt,Rachana Mehta,Gina Miller,Lynn Smith,Rose Ann Smith,Tahseen Mozaffar,I. Hernandez,K. S. Moulton,Chafic Karam,Pranali Ravikumar,Catherine Lomen-Hoerth,La Vergne Rosow,Hannah C George,Viktoriya S. Irodenko,Carol Denny,Sara Klein,Jennifer M. Martinez-Thompson,Elie Naddaf,Denny J. Padgett,Eric M. Sorenson,Kourosh Rezania,Jason R. Thonhoff,Sheetal Shroff,Robert M. Pascuzzi,Angela Micheels,Cynthia Bodkin,Adam Comer,Renee Wagner,Zabeen Mahuwala,Stephen A. Ryan,Kai-Hua Su,Khema R. Sharma,Andrew W. Brown,K.L. Liow +243 more
TL;DR: Reductions in MG-ADL score from baseline to day 43 were greater in the rozanolixizumab 7 mg/kg group than with placebo, and the primary efficacy endpoint was change from baseline-to-day 43 inMG- ADL score, assessed in the intention- to-treat population.
Clinical Effects of the Self-administered Subcutaneous Complement Inhibitor Zilucoplan in Patients With Moderate to Severe Generalized Myasthenia Gravis: Results of a Phase 2 Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Trial
James F. Howard,Richard Nowak,Gil I. Wolfe,Miriam L. Freimer,Tuan Vu,John L. Hinton,Michael Benatar,Petra W. Duda,James E. MacDougall,Ramin Farzaneh-Far,Henry J. Kaminski,Richard J. Barohn,Mazen M. Dimachkie,Mamatha Pasnoor,Constantine Farmakidis,Tina Liu,Samantha Colgan,Michael Benatar,Tulio E. Bertorini,Rekha Pillai,Robert Henegar,Mark B. Bromberg,Summer Gibson,Teresa Janecki,Miriam Freimer,Bakri Elsheikh,Paige Matisak,Angela Genge,Amanda C. Guidon,William S. David,Ali Habib,Veena Mathew,Tahseen Mozaffar,William Hewitt,Deborah Barnett,Patricia Sullivan,Doreen T. Ho,Rebecca Traub,Manisha Chopra,Radwa Aly,Elham Bayat,Mohammad Abu-Rub,Shaida Khan,Dale J. Lange,Shara Holzberg,Bhupendra O. Khatri,Emily Lindman,Tayo Olapo,Lisa M. Sershon,Robert P. Lisak,Evanthia Bernitsas,Kelly Jia,Rabia Malik,Tiffany D. Lewis-Collins,Michael W. Nicolle,Aditi Sharma,Bhaskar Roy,Joan Nye,Michael Pulley,Alan R. Berger,Yasmeen Shabbir,Amit H. Sachdev,Kimberly Patterson,Zaeem A. Siddiqi,Mark Sivak,Joan Bratton,George A. Small,Anem Kohli,Mary Fetter,Tuan Vu,Lucy Lam,Brittany Harvey,Nicholas Silvestri,Kara Patrick,Karen Zakalik,James MacDougall,Angela Pontius,Michelle Hoarty +77 more
TL;DR: The findings support a potential therapeutic role for zilucoplan in generalized myasthenia gravis and further evaluation in a phase 3 study.