Lucy E. Cain
Children's Hospital at Westmead
8 Papers
1 Citations
Lucy E. Cain is an academic researcher from Children's Hospital at Westmead. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 1, co-authored 2 publications.
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Papers
A quantitative universal NGS-based circulating tumor DNA assay for hepatoblastoma
Smadar Kahana-Edwin,James Torpy,Lucy E. Cain,Alan Mullins,G McCowage,Sarah E. Woodfield,Swetha Vasudevan,D. Shea,André E. Minoche,S. Kummerfeld,LC Goldstein,Jonathan Karpelowsky +11 more
TL;DR: Approximate quantitation of various variants including single base substitutions and deletions down to 0.3% variant allele frequency is demonstrated to allow biopsy-free tumor genotyping and sensitive ct DNA quantitation, providing promising evidence for the utility of quantitative ctDNA detection in hepatoblastoma.
Quantitative ctDNA Detection in Hepatoblastoma: Implications for Precision Medicine
Smadar Kahana-Edwin,James Torpy,Lucy E. Cain,Anna Mullins,Geoffrey McCowage,Sarah E. Woodfield,Sanjeev A. Vasudevan,Dan P. T. Shea,André E. Minoche,Andres F Espinoza,Sarah Kummerfeld,Leonard D. Goldstein,Jonathan Karpelowsky +12 more
TL;DR: There is promising evidence for the utility of quantitative CTNNB1 ctDNA detection in hepatoblastoma for dynamic tumor burden and treatment response monitoring, compared with the current clinical indicators and biomarkers for this disease.
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Paediatric Experience of Chimeric Antigen Receptor T-Cell Therapy for Relapsed/Refractory Philadelphia Chromosome-Positive Acute Lymphoblastic Leukaemia
Lucy E. Cain,Milica Araya,Draga Barbaric,Laura R.M. Chapman,Neevika Manoharan,Lucy Maurice,K. Kimberly McCleary,Richard Mitchell,Tracey A. O'Brien,Cecilia Oswald,Toby Trahair,Annette Trickett,Adam S. Nelson +12 more
Donor Selection in a Geographically Isolated Country during the COVID-19 Pandemic
Laura R.M. Chapman,Cecilia Oswald,Lucy E. Cain,Milica Araya,N. Coulits,Lucy Maurice,K. Kimberly McCleary,Jonathan Moses,Richard Mitchell,Tracy A. O`Brien,Felicity A. Wright,Annette Trickett,Adam S. Nelson +12 more
TL;DR: This research presents a novel approach to cell reprograming called “smart reprogramming” that allows for real-time, 3D image analysis of the response of the immune system to single-cell transplants.
Haematopoietic Progenitor Cell Mobilisation Following Blinatumomab Therapy
Lucy E. Cain,Katherine R. Stephen,Vicki Antonenas,Kay Montgomery,Belinda Meares,Melissa Gabriel +5 more
TL;DR: In this article , the authors report their experience with HPC mobilisation for autologous back-up harvest in paediatric patients with ALL treated with blinatumomab.