Lucilla Varoli
University of Bologna
36 Papers
198 Citations
Lucilla Varoli is an academic researcher from University of Bologna. The author has contributed to research in topics: Diastereomer & Chemistry. The author has an hindex of 14, co-authored 36 publications. Previous affiliations of Lucilla Varoli include Malaghan Institute of Medical Research.
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Papers
New isatin derivatives with antioxidant activity.
Aldo Andreani,Silvia Burnelli,Massimiliano Granaiola,Alberto Leoni,Alessandra Locatelli,Rita Morigi,Mirella Rambaldi,Lucilla Varoli,Mauro Andrea Cremonini,Giuseppe Placucci,Rinaldo Cervellati,Emanuela Greco +11 more
TL;DR: Three published antitumor agents showed a good chemical antioxidant activity and the main product was identified as 3,3-bis(4-amino-2,5-dimethoxyphenyl)-1-3-dihydroindol-2-one.
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Antitumor activity of new substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and 3-(5-imidazo[2,1-b]thiadiazolylmethylene)-2-indolinones: selectivity against colon tumor cells and effect on cell cycle-related events.
Aldo Andreani,Silvia Burnelli,Massimiliano Granaiola,Alberto Leoni,Alessandra Locatelli,Rita Morigi,Mirella Rambaldi,Lucilla Varoli,Natalia Calonghi,Concettina Cappadone,Manuela Voltattorni,Maddalena Zini,Claudio Stefanelli,Lanfranco Masotti,Robert H. Shoemaker +14 more
TL;DR: Its ability to inhibit cellular proliferation was mediated by cell cycle arrest at the G2/M phase, accompanied by inhibition of ornithine decarboxylase (ODC), the limiting enzyme of polyamine synthesis, and followed by induction of apoptosis.
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Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action.
Aldo Andreani,Massimiliano Granaiola,Alessandra Locatelli,Rita Morigi,Mirella Rambaldi,Lucilla Varoli,Natalia Calonghi,Concettina Cappadone,Giovanna Farruggia,Claudio Stefanelli,Lanfranco Masotti,Tam Luong Nguyen,Ernest Hamel,Robert H. Shoemaker +13 more
TL;DR: The most potent compounds strongly and selectively inhibited the phosphorylation of the oncoprotein kinase Akt in cancer cells and caused the cells to arrest in the G2/M phase of the cell cycle, as would be expected for inhibitors of tubulin assembly.
Acidity constants of sparingly water‐soluble drugs from potentiometric determinations in aqueous dimethyl sulfoxide
TL;DR: A brief analysis of the acid-base equilibria in pure organic solvents and/or in their aqueous mixtures is reported with the aim of determining dissociation constants of acidic drugs that are sparingly soluble in water.
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Stereoselective binding of 2,3-substituted 3-hydroxypropionic acids on an immobilised human serum albumin chiral stationary phase: stereochemical characterisation and quantitative structure-retention relationship study.
Vincenza Andrisano,Carlo Bertucci,Vanni Cavrini,Maurizio Recanatini,Andrea Cavalli,Lucilla Varoli,G. Félix,Irving W. Wainer +7 more
TL;DR: The binding characteristics of a series of 2,3-substituted 3-hydroxypropionic acids, with anti-inflammatory properties, bearing two chiral centres, were studied by HPLC upon HSA (human serum albumin)-based stationary phase to have insight into the chiral recognition mechanism.
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