Luca Steardo
University of Palermo
27 Papers
101 Citations
Luca Steardo is an academic researcher from University of Palermo. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 17, co-authored 27 publications.
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Papers
CRF system recruitment mediates dark side of compulsive eating
Pietro Cottone,Valentina Sabino,Marisa Roberto,Michal Bajo,Lara Pockros,J.B. Frihauf,Eva M. Fekete,Luca Steardo,Kenner C. Rice,Dimitri E. Grigoriadis,Bruno Conti,George F. Koob,Eric P. Zorrilla +12 more
TL;DR: It is proposed that recruitment of anti-reward extrahypothalamic CRF-CRF1 systems during withdrawal from palatable food, analogous to abstinence from abused drugs, may promote compulsive selection of palatableFood, undereating of healthier alternatives, and a negative emotional state when intake ofPalatable food is prevented.
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Prenatal Exposure to the CB1 Receptor Agonist WIN 55,212-2 Causes Learning Disruption Associated with Impaired Cortical NMDA Receptor Function and Emotional Reactivity Changes in Rat Offspring
Tiziana Antonelli,Maria Cristina Tomasini,Maria Tattoli,Tommaso Cassano,Sergio Tanganelli,Simone Finetti,Elisa Mazzoni,Luigia Trabace,Luca Steardo,Vincenzo Cuomo,Luca Ferraro +10 more
TL;DR: Evidence is provided for a deficit in cortical glutamatergic neurotransmission and behaviour in the rat neonate following prenatal exposure to WIN and it is suggested that the reduction in cortical glutamate levels, NMDA receptor activity and alterations in neuronal development might underlie, at least in part, the learning deficit and decreased emotional reactivity observed in the offspring.
Intermittent access to preferred food reduces the reinforcing efficacy of chow in rats
TL;DR: The results suggest that intermittent access to highly preferred food, as practiced by many restrained eaters, may progressively decrease the acceptability of less palatable foods, and may promote relapse to more rewarding alternatives.
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Withdrawal from chronic, intermittent access to a highly palatable food induces depressive-like behavior in compulsive eating rats
Attilio Iemolo,Marta Valenza,Lisa Tozier,Clifford M. Knapp,Conan Kornetsky,Luca Steardo,Valentina Sabino,Pietro Cottone +7 more
TL;DR: The hypothesis that withdrawal from highly palatable food is responsible for the emergence of depressive-like behavior is validated, and results show that compulsive eating relieves the withdrawal-induced negative emotional state.
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Altered Waste Disposal System in Aging and Alzheimer's Disease: Focus on Astrocytic Aquaporin-4.
TL;DR: The latest findings related to aging and Alzheimer’s disease (AD) on this topic are reviewed, as well as the available knowledge on pharmacological tools to target AQP-4.
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